WHO histologic typing of tumors of the thymus

Epithelial tumors

Thymoma

Thymoma, NOS

Type A

Type AB

Type B1

Type B2

Type B3

Micronodular thymoma with lymphoid stroma

Metaplastic thymoma

Lipofibroadenoma

Thymic carcinomas

Squamous cell carcinomas

Squamous cell carcinoma, NOS

Basaloid carcinoma

Lymphoepithelioma-like carcinoma

Adenocarcinomas

Adenocarcinoma, NOS

Low-grade papillary adenocarcinoma

Thymic carcinoma with adenoid cystic carcinoma-like features

Adenocarcinoma, enteric type

Adenosquamous carcinoma

NUT carcinoma

Salivary gland-like carcinomas

Mucoepidermoid carcinoma

Clear cell carcinoma

Sarcomatoid carcinoma

Carcinosarcoma

Undifferentiated carcinoma

Carcinoma, undifferentiated, NOS

Thymic carcinoma, NOS

Neuroendocrine tumors

Carcinoid tumor, NOS/neuroendocrine tumor, NOS

Typical carcinoid/neuroendocrine tumor, grade 1

Atypical carcinoid/neuroendocrine tumor, grade 2

Neuroendocrine carcinomas

Small cell carcinoma

Combined small cell carcinoma

Large cell neuroendocrine carcinoma

NUT: nuclear protein in testis; NOS: not otherwise specified.

Adapted with permission from: WHO Classification of Tumours Editorial Board. Thoracic tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2021. (WHO classification of tumours series, 5th ed.; vol. 5). Copyright © 2021.

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WHO histologic typing of tumors of the thymus