Further evaluation of the patient with selective IgM deficiency

Other studies of specific antibody production

Isohemagglutinins (antibody to blood group antigens A and B)

Response to neoantigens (bacteriophage fX174 or keyhole limpet hemocyanin)*

IgG subclass levels

IgG 1, 2, 3, and 4

B and T lymphocyte evaluation

Immunophenotyping of B cells*

CD19+/CD20+/sIgMD+ (immature B cell)

CD19+/CD20+/sIgMD+/sIgDD+ (mature B cell)

CD19+/CD20+/sIgMD+/sIgDD+/CD27+ (memory B cell)

In vitro lymphocyte responses*

B cell proliferation response to SAC

IgM production by B cells in response to SAC and BCDF

Suppressor activity of B cells specific for IgM

IgM: immunoglobulin M; IgG: immunoglobulin G; sIgMD: selective immunoglobulin M deficiency; sIgDD: selective immunoglobulin D deficiency; SAC: Staphylococcus aureus Cowan strain 1; BCDF: B cell differentiation factor.
* May only be available in specialized centers and research laboratories.

Graphic 52719 Version 10.0

خرید پکیج

Further evaluation of the patient with selective IgM deficiency