This figure shows the two-hour recovery in the general circulation of radioactively-labeled platelets transfused to asplenic (red), normal (green), and splenomegalic (orange) patients. The vast majority of the splenomegalic patients had congestive splenomegaly secondary to cirrhosis with portal hypertension.
Adapted from: Aster RH. Pooling of platelets in the spleen: role in the pathogenesis of 'hypersplenic' thrombocytopenia. J Clin Invest 1966; 45:645.
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