Cytogenetic abnormality | Approximate percent of MGUS | Genes dysregulated by cytogenetic changes |
Primary IgH translocations involving chromosome 14q32 (non-hyperdiploid MGUS) | ||
t(11;14)(q13;q32) | 25% | CCND1 (cyclin D1) |
t(4;14)(p16;q32) | 15% | FGFR-3 and MMSET/WHSC1 |
t(14;16)(q32;q23) | 5% | C-MAF |
t(6;14)(p21;q32) | 3% | CCND3 (cyclin D3) |
t(14;20)(q32;q11) | 2% | MAFB |
Hyperdiploidy (hyperdiploid MGUS) | ||
45% | Multiple genes dysregulated due to recurrent trisomies involving odd-numbered chromosomes with exception of chromosomes 1, 13, and 21 | |
Unknown | ||
<5% | Neither IgH translocation nor hyperdiploidy |
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