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Potential antigens of group B streptococcus for use as vaccines

Potential antigens of group B streptococcus for use as vaccines
Antigen Virulence factor Studies performed with prototype vaccines:
Preclinical Clinical
Carbohydrates
group B antigen no yes no
Ia CPS yes yes Phases 1 and 2
Ib CPS yes yes Phases 1 and 2
II CPS yes yes Phases 1 and 2
III CPS yes yes Phases 1 and 2
IV CPS yes yes Phases 1 and 2
V CPS yes yes Phases 1 and 2
VI CPS yes yes no
VIII CPS yes yes no
IX CPS  yes no  no 
Proteins
C proteins
alpha yes yes no
beta ? yes no
epsilon ? no no
Rib ? yes no
Rib/Alpha C yes yes Phase 1
R-proteins ? no no
Type V/VIII alpha-like proteins ? yes no
C5a peptidase yes yes no
Sip yes yes  
LrrG  yes  yes  no 
Pili islands PI-1, PI-2a, PI-2b yes  yes  no 
CPS: capsular polysaccharide.
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