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Brain MRI of a 5-year-old patient with Pelizaeus-Merzbacher disease (PMD) in comparison with an age-matched normal brain MRI

Brain MRI of a 5-year-old patient with Pelizaeus-Merzbacher disease (PMD) in comparison with an age-matched normal brain MRI
Brain MRI of a 5-year-old with Pelizaeus-Merzbacher disease (PMD) compared with an age-matched normal brain MRI (Normal). In physiologic conditions, the myelinated white matter has a hypersignal T1, and hyposignal T2 and FLAIR when compared with gray matter. In PMD, the hypomyelinated white matter has a normal hypersignal T1 appearance contrasting with an abnormal hypersignal T2 and FLAIR. The corpus callosum is partially myelinated with a hyposignal T2 but not with FLAIR.
FLAIR: fluid-attenuated inversion recovery; MRI: magnetic resonance imaging.
From: Khalaf G, Mattern C, Begou M, et al. Mutation of proteolipid protein 1 gene: From severe hypomyelinating leukodystrophy to inherited spastic paraplegia. Biomedicines 2022; 10:1709. Copyright © 2022 The Authors. Available at: https://www.mdpi.com/2227-9059/10/7/1709 (Accessed on January 10, 2024). Reproduced under the terms of the Creative Commons Attribution License 4.0.
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