Brain MRI of a 5-year-old patient with Pelizaeus-Merzbacher disease (PMD) in comparison with an age-matched normal brain MRI
Brain MRI of a 5-year-old with Pelizaeus-Merzbacher disease (PMD) compared with an age-matched normal brain MRI (Normal). In physiologic conditions, the myelinated white matter has a hypersignal T1, and hyposignal T2 and FLAIR when compared with gray matter. In PMD, the hypomyelinated white matter has a normal hypersignal T1 appearance contrasting with an abnormal hypersignal T2 and FLAIR. The corpus callosum is partially myelinated with a hyposignal T2 but not with FLAIR.