Serum LH and FSH concentrations in an ovariectomized monkey. Pulsatile administration (given for six minutes every hour) of GnRH maintains serum FSH and LH concentrations. In comparison, a continuous infusion of GnRH (middle panel) leads to rapid and reversible suppression of both LH and FSH release.
Data from: Belchetz PE, Plant TM, Nakai Y, et al. Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science 1978; 202:631.
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