Ambulatory ePAD during progression of diastolic heart failure

Changes in LV diastolic pressure as reflected by ambulatory 24-hour median pulmonary artery diastolic pressures (ePAD) in a patient with diastolic HF. Time zero represents the day of hospitalization for acute decompensated HF and Day -60 marks 60 days prior to the onset of this event. As shown, LV diastolic pressure is elevated even with compensated HFpEF and then rises as diastolic HF worsens. Following treatment, the diastolic pressure falls to a level close to that in the preceding compensated phase.