Features of infantile hemangiomas with highest risk for morbidity according to anatomic location and/or morphology of the hemangioma

Anatomic location/morphology	Associated risk
Facial, large segmental	PHACES syndrome (posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal clefting)
Nasal tip, ear, large facial (especially with prominent dermal component)	Permanent scarring, disfigurement
Periorbital and retrobulbar	Ocular axis occlusion, astigmatism, amblyopia, tear-duct occlusion
Segmental "beard area," central neck	Airway hemangioma
Perioral	Ulceration, disfigurement, feeding difficulties
Segmental overlying lumbosacral spine	Tethered spinal cord, genitourinary anomalies
Perineal, axilla, neck, perioral	Ulceration
Multiple hemangiomas	Visceral involvement (especially liver, gastrointestinal tract)

IH_features_morbidity.htm

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