ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Diaphragmatic paralysis in the newborn

Diaphragmatic paralysis in the newborn
Literature review current through: Jan 2024.
This topic last updated: Apr 30, 2023.

INTRODUCTION — The most important of the respiratory muscles is the dome-shaped diaphragm, which separates the thoracic and abdominal cavities and is innervated by the phrenic nerve. Injury to the phrenic nerve associated with birth trauma or cardiothoracic surgery can result in diaphragmatic paralysis, which may lead to respiratory distress in newborns. The initial treatment is supportive, and spontaneous recovery occurs in most cases.

Before addressing the clinical features, diagnosis, and management of the disorder, reviewing the embryology and physiology of the diaphragm is useful.

DIAPHRAGM EMBRYOLOGY — The diaphragm develops from four embryologic structures:

Septum transversum

Pluripotential membranes

Dorsal mesentery of the esophagus

Body wall muscles

The septum transversum is first recognizable at the third week of gestation as a mass of mesoderm located ventral to the cervical somites. During the fourth week, it descends and partially separates the thoracic and peritoneal cavities [1]. The openings that remain between the thorax and abdomen are the pleuroperitoneal ducts.

During the fifth week of gestation, myoblasts and neuronal elements from the third, fourth, and fifth cervical somites penetrate the developing diaphragm as the downward migration of the septum transversum continues. As a result, the phrenic nerve is comprised of the third, fourth, and fifth cervical nerve roots [2]. The migration continues until the eighth week of gestation. At that time, the septum transversum fuses with the pluripotential membranes and the mesenchyme ventral to the esophagus, closing the pleuroperitoneal ducts [1].

DIAPHRAGM PHYSIOLOGY — The diaphragm has two components: the noncontractile central tendon and the contracting muscle fibers. It is innervated by cervical motor neurons three, four, and five, conducted via the homolateral phrenic nerve through the neck and mediastinum.

Contraction of the diaphragm has the following effects that promote air movement into the lungs [3,4]:

It decreases intrapleural pressure.

It raises or inflates the rib cage using the abdomen as a fulcrum on which to lean.

It expands the rib cage through its zone of apposition (the lower third of the rib cage apposed by the diaphragm) by generating positive intraabdominal pressure.

In the adult, the diaphragmatic muscle fibers radiate circumferentially and insert peripherally into the inner surface of the lower six ribs and costal cartilages anteriorly (costal part), and the upper three lumbar vertebral bodies posteriorly (crural part). Anatomical differences between the newborn and adult result in decreased efficiency of the neonatal diaphragm.

Neonatal diaphragm — Compared with the adult, the newborn diaphragm differs in its attachment to the rib cage, its flatter shape, and its fiber composition [5,6]. Inefficiency of the diaphragm may be exacerbated by the newborn's highly compliant rib cage and horizontal configuration of the ribs, which reduce the mechanical advantage of the intercostal muscles in lifting the rib cage in inspiration. The newborn's recumbent posture, compared with that of the upright adult, also contributes to diaphragm inefficiency.

Rib cage attachments — The attachments of the diaphragm to the rib cage render the neonatal diaphragm less efficient than that of the adult. In the newborn, muscle fibers from the anterior diaphragm radiate laterally and attach to the xiphoid process and the seventh rib [7]. Fibers from the posterior diaphragm join the eleventh rib, while posterolateral fibers blend with the transverse abdominal muscles. The large angle of insertion into the lateral wall limits the zone of apposition. As a result, most of the movement of the neonatal diaphragm is in the posterior portion, in contrast to the piston-like movement of the adult diaphragm [8].

Pressure generation — Because the neonatal diaphragm is flatter (that is, it has a larger radius of curvature) than that of the adult, the maximum transdiaphragmatic pressure generated by contraction is less [7]. This is expressed by Laplace's law:

                                             P = 2T / r

where P is the transdiaphragmatic pressure, T is the tension developed by the diaphragm, and r is the radius of curvature of the diaphragm.

Fiber types — Adult and neonatal diaphragms differ in the relative proportion of type I and II muscle fibers, which affects their ability to withstand fatigue. Type I fibers are recruited first and generate a low level of force; they are relatively resistant to fatigue. Type II fibers are the last to be recruited, generate a high level of force, and are easily fatigued [9]. The proportion of fatigue-resistant type I fibers is less in the neonatal diaphragm compared with in that of the adult (25 versus 55 percent) [10].

Body position — The diaphragm is less efficient in the recumbent newborn than in the upright adult. In addition, diaphragmatic function may be impaired more in the prone than supine position. In one study, diaphragm thickness and shortening were assessed by ultrasound in healthy term infants [11]. In the prone position, the diaphragm was thicker and shorter at both end-expiratory and end-inspiratory volumes, and diaphragm shortening was greater during tidal breathing, compared with in the supine position. The reduced resting diaphragmatic length in the prone position would be expected to impair diaphragmatic strength, while the additional shortening during tidal breathing would increase diaphragmatic work.

ETIOLOGY — Diaphragmatic paralysis typically is caused by injury to the phrenic nerve. In almost all cases, this is caused by trauma during birth or cardiothoracic surgery. In rare cases, paralysis results from neuromuscular disorders [12,13].

Birth injury — Extreme lateral traction on the shoulder during delivery can injure or transect the phrenic nerve and/or the brachial plexus by stretching their cervical roots [14]. The traction occurs during delivery of the shoulder in cephalic presentations and delivery of the head in breech presentations [15].

Involvement of the third to fifth, and especially the fourth, cervical roots results in diaphragmatic paralysis. Brachial plexus palsy is associated in 80 to 90 percent of cases, while diaphragmatic paralysis occurs in approximately 5 percent of brachial plexus injuries [15,16].

Factors associated with diaphragmatic paralysis are similar to those associated with brachial plexus injury. The risk of brachial plexus injury is greatly increased by vaginal delivery of a macrosomic infant (>4500 g) (odds ratio 21, compared with normal weight) [14,17]. Shoulder dystocia may be a contributing factor. In one review, shoulder dystocia complicated the delivery of 75 percent of macrosomic infants with brachial plexus injury [18]. Diaphragmatic paralysis occurs more often after breech than after cephalic deliveries [15]. Malpositioned forceps also may result in phrenic nerve injury [19].

Cardiothoracic surgery — Phrenic nerve injury is a recognized complication of cardiothoracic surgery [20]. Causes include electrocauterization, stretching, blunt trauma, or complete denervation [21]. The incidence of clinically diagnosed diaphragmatic paralysis after cardiothoracic surgery in children is variable, ranging from 0.5 to 2.2 percent of open and closed procedures in retrospective studies [21-24]. The incidence may be slightly higher (3 to 4.6 percent) in infants and younger children, and occurs most often after Blalock-Thomas-Taussig shunts (commonly called Blalock-Taussig shunts) are performed [25,26].

Prospective assessment of injury by percutaneous stimulation of the phrenic nerve detected a higher rate of injury than did retrospective studies. In one report, unilateral phrenic nerve injury was detected after cardiac surgery in 6 of 50 infants and 4 of 50 children younger than 15 years of age [27]. All were symptomatic. No associations were found with age, type of surgery, length of bypass, aortic clamping, circulatory arrest, or degree of hypothermia.

Other procedures — Other procedures that may be performed in sick newborns can lead to phrenic nerve injury, although this complication seldom occurs. Diaphragmatic paralysis has been reported after cannulation of the internal jugular [28] or subclavian vein [29]. The disorder also has been associated with insertion of chest tubes [30,31] and repair of esophageal atresia/tracheoesophageal fistula [32].

Neuromuscular disorders — Neuromuscular disorders are rare causes of diaphragmatic paralysis [12]. Causes identified in case reports include congenital myopathies [13,33], spinal muscular atrophy [34], myasthenia [35], and congenital diaphragmatic muscle hypoplasia [36]. Other causes include high spinal cord trauma and botulism.

CLINICAL FEATURES — Diaphragmatic paralysis occurring after birth injury typically is unilateral. The right side is involved most often (approximately 80 percent of cases) [15]. The most severely affected infants have bilateral involvement, which occurs in less than 10 percent [15,37,38].

Onset — The onset of symptoms is variable and may occur soon after birth or later in the neonatal period. Recognition may be delayed in infants receiving assisted ventilation. These patients usually do not become symptomatic until weaning from the ventilator is attempted.

Newborns tolerate diaphragmatic paralysis less well than older children or adults. Their anatomic differences result in increased respiratory dysfunction and earlier presentation. (See 'Neonatal diaphragm' above.)

Phrenic nerve injury associated with cardiothoracic surgery or other procedures usually is suspected when the infant cannot be weaned from the ventilator or develops respiratory distress after extubation [39]. Some infants present with complications of diaphragmatic paralysis, such as atelectasis, pleural effusions, aspiration, or respiratory infections [21,27].

Signs — Affected newborns typically have signs of respiratory compromise. These include tachypnea, mild to severe respiratory distress, cyanosis, apnea, or a weak cry.

Some affected infants also have gastrointestinal symptoms. These typically include respiratory distress or tiring during feedings [40]. Patients with left-sided diaphragmatic paralysis may have frequent regurgitation as a result of displacement of the lower esophagus and/or stomach [41].

Most infants with diaphragmatic paralysis caused by birth injury have an associated brachial plexus palsy [15,16]. This is usually the proximal type (Erb palsy), although it may be total. The affected limb typically assumes the characteristic "waiter's tip" position.

PHYSICAL EXAMINATION — Affected infants may have decreased movement of the rib cage on the affected side, with corresponding prominent movement of the unaffected side. This paradoxical movement of the diaphragm (ie, rising with inspiration and falling with expiration, also known as Kienboeck sign) may result in a "seesaw" movement of the abdomen. This "seesaw" movement may be absent in infants receiving positive pressure ventilation or continuous positive airway pressure (CPAP) because the affected diaphragm may not be elevated or move paradoxically. Rare infants have the "belly dancer's sign" in which the umbilicus moves toward the affected side during inspiration [42].

Auscultation usually detects decreased air entry on the affected side. If the right diaphragm is affected, percussion (although rarely part of the newborn examination) may reveal dullness at the right lung base caused by the cephalic displacement of the liver [43]. Hyperresonance may occur over the left lung base if the left side is affected, due to the cephalic displacement of the gastric bubble.

DIAGNOSIS

When to suspect diaphragmatic paralysis — Diaphragmatic paralysis should be considered when respiratory dysfunction develops after a traumatic delivery, especially in a large infant with breech presentation. However, respiratory distress and hypoxemia may also indicate primary pulmonary disease or congenital heart disease, so these diagnoses should be excluded. Diaphragmatic paralysis should also be considered when weaning from mechanical ventilation is unsuccessful after the child has undergone cardiothoracic surgery or another procedure, such as chest tube placement.

Confirming the diagnosis — We confirm the diagnosis of diaphragmatic paralysis with ultrasound; bedside echocardiography can also be used. In a spontaneously breathing infant with diaphragmatic paralysis, we typically see paradoxical diaphragmatic movement (ie, rising with inspiration and falling with expiration). However, the absence of paradoxical diaphragmatic movement does not exclude the possibility of diaphragmatic paralysis. In infants receiving positive pressure ventilation or continuous positive airway pressure (CPAP), the affected diaphragm may not be elevated or move paradoxically. Diagnosis in these infants is difficult unless ultrasound can be done while they are spontaneously breathing.

Although we generally use bedside ultrasound, fluoroscopy can also confirm the diagnosis. We prefer ultrasound because it provides functional and dynamic images that can simplify diagnosis [44]. It also has the advantage of being done at the bedside and involves no exposure to ionizing radiation [45,46]. In addition, one study suggested that echocardiography was more reliable than fluoroscopy in detecting hemidiaphragms that required surgical plication [47]. It is even possible for the diagnosis to be made as an incidental finding on echocardiogram in the post-cardiac surgery infant [48].

Other imaging tests

Radiography – The affected hemidiaphragm typically is elevated on an anteroposterior chest radiograph (image 1). In general, an affected right hemidiaphragm is at least two intercostal spaces higher than the left, and an affected left hemidiaphragm is one intercostal space higher than the right [40]. Other radiographic findings that may be seen include atelectasis on the affected side and shift of the mediastinum away from that side. The stomach bubble may appear elevated with left-sided paralysis.

Magnetic resonance imaging (MRI) – Evaluation of the upper cervical spinal cord with MRI may be useful in infants who present with diaphragmatic paralysis and quadriparesis. In a small series, this technique was used to demonstrate the extent and severity of the injury [49].

Limited role of electromyography and physiologic testing — Other methods are available to assess neonatal diaphragmatic function but are not used clinically because they are difficult to interpret and/or invasive. These include electromyography, measurement of maximal inspiratory pressure during crying, and phrenic nerve stimulation [20,27,50-52]. The technique of magnetic stimulation of the phrenic nerve may be a useful and noninvasive way to assess function, but remains investigational in newborns [50].

MANAGEMENT — Initial treatment of diaphragmatic paralysis is supportive. With supportive care, spontaneous recovery of diaphragmatic function occurs in most cases.

Mildly affected infants may respond to supplemental oxygen administered by hood or nasal cannula. If oral feedings are limited because of respiratory distress, nasogastric feedings can be used to provide adequate nutrition.

More severely affected infants require mechanical ventilation. In less severe cases, continuous positive airway pressure (CPAP) may "splint" the diaphragm, reducing paradoxical motion, and allowing the infant to breathe spontaneously [53,54]. Negative pressure ventilation also has been used [55,56]. Although the technique is cumbersome, it avoids endotracheal intubation.

Outcome — Most newborns with diaphragmatic paralysis associated with birth trauma recover in the first 6 to 12 months after birth with supportive care. Conservative management also usually is successful after cardiac surgery [26]. In some cases, symptoms will resolve with little objective evidence of improved diaphragmatic function [40].

Diaphragmatic paralysis caused by avulsion of the phrenic nerve is permanent. Loss of contraction leads to muscle atrophy and eventration of the diaphragm. (See "Eventration of the diaphragm in infants".)

Surface recordings of diaphragmatic action potential amplitudes and phrenic nerve conduction times in response to percutaneous phrenic nerve stimulation may help predict whether recovery will occur [15,57]. Patients with absent or markedly reduced diaphragmatic action potentials or very prolonged conduction latencies are unlikely to recover and likely will need surgical plication.

Surgical treatment — If patients have persistent severe respiratory distress or a prolonged requirement for mechanical ventilation, surgical plication is performed. This procedure immobilizes and lowers the diaphragm, resulting in increased resting lung volume and improved action of the intercostal and abdominal muscles during breathing. Respiratory improvement after application of CPAP (8 to 10 cm H2O) may identify patients who will respond to plication because both interventions stabilize the diaphragm and increase functional residual capacity [58].

The appropriate timing for performing surgical plication is uncertain. In general, the procedure is considered if mechanical ventilation is required for at least two months and there are no signs of recovery [15]. However, some clinicians recommend earlier intervention to prevent complications of long-term mechanical ventilation, especially when injury follows cardiothoracic surgery or birth injury [14,59].

Outcome — Plication usually is associated with rapid improvement in uncomplicated cases [23,60-62]. In general, mechanical ventilation can be discontinued within one week of surgery, even in preterm infants [63,64].

Data on long-term outcomes following plication are limited. In one report, six children with phrenic nerve injury due to surgery for congenital heart disease or birth trauma had return of normal function one to seven years following diaphragmatic plication [65].

Pacing — Diaphragmatic pacing may be considered in bilateral diaphragmatic paralysis, although experience in young infants is limited [66-69]. However, it is not helpful in unilateral paralysis because of the difficulty of synchronizing contraction of the normal and paralyzed hemidiaphragms.

SUMMARY AND RECOMMENDATIONS

Etiology – Diaphragmatic paralysis typically is caused by injury to the phrenic nerve. In almost all cases, this is caused by trauma during birth or cardiothoracic surgery. In rare cases, paralysis results from neuromuscular disorders. (See 'Etiology' above.)

Clinical features – Diaphragmatic paralysis occurring after birth injury usually is unilateral, and more commonly involves the right side. The onset of symptoms is variable and typically includes signs of respiratory distress, cyanosis, apnea, or a weak cry. Other associated findings include respiratory distress or tiring during feedings, gastrointestinal reflux, and brachial plexus palsy. (See 'Clinical features' above.)

Physical examination – The physical examination includes decreased movement of the rib cage on the affected side, with corresponding prominent movement of the unaffected side. There may also be a seesaw movement of the abdomen. Auscultation of the chest usually detects decreased air entry on the affected side. (See 'Physical examination' above.)

Diagnosis – The diagnosis of diaphragmatic paralysis is confirmed by detecting paradoxical diaphragmatic movement (ie, rising with inspiration and falling with expiration) on ultrasound or echocardiography. Fluoroscopy can also make the diagnosis but involves ionizing radiation and cannot be performed at the bedside. An elevated hemidiaphragm on an anteroposterior chest radiograph is indicative of diaphragmatic paralysis. Other radiographic findings include atelectasis on the affected side, and shift of the mediastinum away from the affected side. (See 'When to suspect diaphragmatic paralysis' above and 'Diagnosis' above.)

Supportive treatment – Initial treatment of diaphragmatic paralysis is supportive. With supportive care, spontaneous recovery of diaphragmatic function occurs in most cases. Supportive care includes supplemental oxygen and mechanical ventilation as needed by the infant. (See 'Management' above.)

Surgical treatment – Surgical plication is indicated in patients with persistent severe respiratory distress and/or who require prolonged mechanical ventilation. Generally, surgical plication is associated with rapid improvement in uncomplicated cases, with discontinuation of mechanical ventilation within one week of surgery. (See 'Surgical treatment' above.)

ACKNOWLEDGMENT — The UpToDate editorial staff acknowledges Suzanne K Whitbourne, MD, who contributed to an earlier version of this topic review.

  1. Schumpelick V, Steinau G, Schlüper I, Prescher A. Surgical embryology and anatomy of the diaphragm with surgical applications. Surg Clin North Am 2000; 80:213.
  2. Tarver RD, Godwin JD, Putman CE. Symposium on Nonpulmonary Aspects in Chest Radiology. The diaphragm. Radiol Clin North Am 1984; 22:615.
  3. Roussos C, Macklem PT. The respiratory muscles. N Engl J Med 1982; 307:786.
  4. Rochester DF. The diaphragm: contractile properties and fatigue. J Clin Invest 1985; 75:1397.
  5. Yellin A, Lieberman Y, Barzilay Z. Postoperative unilateral diaphragmatic paralysis in children, a plea for early plication. Thorac Cardiovasc Surg 1991; 39:221.
  6. Mearns AJ. Iatrogenic injury to the phrenic nerve nerve in infants and young children. Br J Surg 1977; 64:558.
  7. Devlieger H, Daniels H, Marchal G, et al. The diaphragm of the newborn infant: anatomical and ultrasonographic studies. J Dev Physiol 1991; 16:321.
  8. Gibson GJ. Diaphragmatic paresis: pathophysiology, clinical features, and investigation. Thorax 1989; 44:960.
  9. Celli B. The diaphragm and respiratory muscles. Chest Surg Clin N Am 1998; 8:207.
  10. Keens TG, Bryan AC, Levison H, Ianuzzo CD. Developmental pattern of muscle fiber types in human ventilatory muscles. J Appl Physiol Respir Environ Exerc Physiol 1978; 44:909.
  11. Rehan VK, Nakashima JM, Gutman A, et al. Effects of the supine and prone position on diaphragm thickness in healthy term infants. Arch Dis Child 2000; 83:234.
  12. Sivan Y, Galvis A. Early diaphragmatic paralysis. In infants with genetic disorders. Clin Pediatr (Phila) 1990; 29:169.
  13. Bergen BJ, Sangalang VE, Aterman K. Isolated myopathic involvement of the diaphragmatic musculature in a neonate. Ann Neurol 1977; 1:403.
  14. Rizeq YK, Many BT, Vacek JC, et al. Diaphragmatic paralysis after phrenic nerve injury in newborns. J Pediatr Surg 2020; 55:240.
  15. Volpe JJ. Injuries of extracranial, cranial, intracranial, spinal cord, and peripheral nervous system structures. In: Neurology of the Newborn, 4th ed, WB Saunders, Philadelphia 2001. p.813.
  16. Donn SM, Faix RG. Long-term prognosis for the infant with severe birth trauma. Clin Perinatol 1983; 10:507.
  17. McFarland LV, Raskin M, Daling JR, Benedetti TJ. Erb/Duchenne's palsy: a consequence of fetal macrosomia and method of delivery. Obstet Gynecol 1986; 68:784.
  18. Gilbert WM, Nesbitt TS, Danielsen B. Associated factors in 1611 cases of brachial plexus injury. Obstet Gynecol 1999; 93:536.
  19. Stauffer UG, Rickham PP. Acquired eventration of the diaphragm in the newborn. J Pediatr Surg 1972; 7:635.
  20. Van Smith C, Jacobs JP, Burke RP. Minimally invasive diaphragm plication in an infant. Ann Thorac Surg 1998; 65:842.
  21. Watanabe T, Trusler GA, Williams WG, et al. Phrenic nerve paralysis after pediatric cardiac surgery. Retrospective study of 125 cases. J Thorac Cardiovasc Surg 1987; 94:383.
  22. Mickell JJ, Oh KS, Siewers RD, et al. Clinical implications of postoperative unilateral phrenic nerve paralysis. J Thorac Cardiovasc Surg 1978; 76:297.
  23. Shoemaker R, Palmer G, Brown JW, King H. Aggressive treatment of acquired phrenic nerve paralysis in infants and small children. Ann Thorac Surg 1981; 32:250.
  24. Zhao HX, D'Agostino RS, Pitlick PT, et al. Phrenic nerve injury complicating closed cardiovascular surgical procedures for congenital heart disease. Ann Thorac Surg 1985; 39:445.
  25. Hamilton JR, Tocewicz K, Elliott MJ, et al. Paralysed diaphragm after cardiac surgery in children: value of plication. Eur J Cardiothorac Surg 1990; 4:487.
  26. Kunovsky P, Gibson GA, Pollock JC, et al. Management of postoperative paralysis of diaphragm in infants and children. Eur J Cardiothorac Surg 1993; 7:342.
  27. Mok Q, Ross-Russell R, Mulvey D, et al. Phrenic nerve injury in infants and children undergoing cardiac surgery. Br Heart J 1991; 65:287.
  28. Pleasure JR, Shashikumar VL. Phrenic nerve damage in the tiny infant during vein cannulation for parenteral nutrition. Am J Perinatol 1990; 7:136.
  29. D'Netto MA, Bender J, Brown RT, Herson VC. Unilateral diaphragmatic palsy in association with a subclavian vein thrombus in a very-low- birth-weight infant. Am J Perinatol 2001; 18:459.
  30. Arya H, Williams J, Ponsford SN, Bissenden JG. Neonatal diaphragmatic paralysis caused by chest drains. Arch Dis Child 1991; 66:441.
  31. Odita JC, Khan AS, Dincsoy M, et al. Neonatal phrenic nerve paralysis resulting from intercostal drainage of pneumothorax. Pediatr Radiol 1992; 22:379.
  32. Man D, Wheildon MH, Eckstein HB. Paralysis of the right hemidiaphragm following primary anastomosis for oesophageal atresia and tracheo-oesophageal fistula. Z Kinderchir 1982; 37:32.
  33. De Reuck J, Hooft C, De Coster W, et al. A progressive congenital myopathy. Initial involvement of the diaphragm with type I muscle fiber atrophy. Eur Neurol 1977; 15:217.
  34. Bertini E, Gadisseux JL, Palmieri G, et al. Distal infantile spinal muscular atrophy associated with paralysis of the diaphragm: a variant of infantile spinal muscular atrophy. Am J Med Genet 1989; 33:328.
  35. Heckmatt JZ, Placzek M, Thompson AH, et al. An unusual case of neonatal myasthenia. J Child Neurol 1987; 2:63.
  36. Bosman C, Bachelet V, Boldrini R, Bertini E. Diaphragmatic paralysis due to partial diaphragmatic hypoplasia mimicking a localized muscular dystrophy: a case report. Clin Neuropathol 1988; 7:33.
  37. Aldrich TK, Herman JH, Rochester DF. Bilateral diaphragmatic paralysis in the newborn infant. J Pediatr 1980; 97:988.
  38. Commare MC, Kurstjens SP, Barois A. Diaphragmatic paralysis in children: a review of 11 cases. Pediatr Pulmonol 1994; 18:187.
  39. Tönz M, von Segesser LK, Mihaljevic T, et al. Clinical implications of phrenic nerve injury after pediatric cardiac surgery. J Pediatr Surg 1996; 31:1265.
  40. Greene W, L'Heureux P, Hunt CE. Paralysis of the diaphragm. Am J Dis Child 1975; 129:1402.
  41. BISHOP HC, KOOP CE. Acquired eventration of the diaphragm in infancy. Pediatrics 1958; 22:1088.
  42. Nichols MM. Shifting umbilicus in neonatal phrenic palsy (the belly dancer's sign). Clin Pediatr (Phila) 1976; 15:342.
  43. Smith BT. Isolated phrenic nerve palsy in the newborn. Pediatrics 1972; 49:449.
  44. Nason LK, Walker CM, McNeeley MF, et al. Imaging of the diaphragm: anatomy and function. Radiographics 2012; 32:E51.
  45. May LA, Epelman M, Navarro OM. Ultrasound imaging of diaphragmatic motion. Pediatr Radiol 2022; 52:2051.
  46. Ricoy J, Rodríguez-Núñez N, Álvarez-Dobaño JM, et al. Diaphragmatic dysfunction. Pulmonology 2019; 25:223.
  47. Miller SG, Brook MM, Tacy TA. Reliability of two-dimensional echocardiography in the assessment of clinically significant abnormal hemidiaphragm motion in pediatric cardiothoracic patients: Comparison with fluoroscopy. Pediatr Crit Care Med 2006; 7:441.
  48. Fontoura A, Cunha G, Horta E, Andrade MJ. The many paths to diagnose diaphragmatic paralysis: Cardiopulmonary ultrasound on stage. Echocardiography 2022; 39:132.
  49. Mills JF, Dargaville PA, Coleman LT, et al. Upper cervical spinal cord injury in neonates: the use of magnetic resonance imaging. J Pediatr 2001; 138:105.
  50. Rafferty GF, Greenough A, Dimitriou G, et al. Assessment of neonatal diaphragm function using magnetic stimulation of the phrenic nerves. Am J Respir Crit Care Med 2000; 162:2337.
  51. Diament MJ, Boechat MI, Kangarloo H. Real-time sector ultrasound in the evaluation of suspected abnormalities of diaphragmatic motion. J Clin Ultrasound 1985; 13:539.
  52. Shardonofsky FR, Perez-Chada D, Milic-Emili J. Airway pressures during crying: an index of respiratory muscle strength in infants with neuromuscular disease. Pediatr Pulmonol 1991; 10:172.
  53. Zajkowski EJ, Kravath RE. Bilateral diaphragmatic paralysis in the newborn infant: treatment with nasal continous positive airway pressure. Chest 1979; 75:392.
  54. Bucci G, Marzetti G, Picece-Bucci S, et al. Phrenic nerve palsy treated by continuous positive pressure breathing by nasal cannula. Arch Dis Child 1974; 49:230.
  55. Raine J, Samuels MP, Mok Q, et al. Negative extrathoracic pressure ventilation for phrenic nerve palsy after paediatric cardiac surgery. Br Heart J 1992; 67:308.
  56. Weisman L, Woodall J, Merenstein G. Constant negative pressure in the treatment of diaphragmatic paralysis secondary to birth injury. Birth Defects Orig Artic Ser 1976; 12:297.
  57. Brouillette RT, Ilbawi MN, Hunt CE. Phrenic nerve pacing in infants and children: a review of experience and report on the usefulness of phrenic nerve stimulation studies. J Pediatr 1983; 102:32.
  58. Haller JA Jr, Pickard LR, Tepas JJ, et al. Management of diaphragmatic paralysis in infants with special emphasis on selection of patients for operative plication. J Pediatr Surg 1979; 14:779.
  59. Jog SM, Patole SK. Diaphragmatic paralysis in extremely low birthweight neonates: Is waiting for spontaneous recovery justified? J Paediatr Child Health 2002; 38:101.
  60. Affatato A, Villagra F, De Leon JP, et al. Phrenic nerve paralysis following pediatric cardiac surgery. Role of diaphragmatic plication. J Cardiovasc Surg (Torino) 1988; 29:606.
  61. Ribet M, Linder JL. Plication of the diaphragm for unilateral eventration or paralysis. Eur J Cardiothorac Surg 1992; 6:357.
  62. Schwartz MZ, Filler RM. Plication of the diaphragm for symptomatic phrenic nerve paralysis. J Pediatr Surg 1978; 13:259.
  63. Smith CD, Sade RM, Crawford FA, Othersen HB. Diaphragmatic paralysis and eventration in infants. J Thorac Cardiovasc Surg 1986; 91:490.
  64. Gallagher PG, Seashore JH, Touloukian RJ. Diaphragmatic plication in the extremely low birth weight infant. J Pediatr Surg 2000; 35:615.
  65. Stone KS, Brown JW, Canal DF, King H. Long-term fate of the diaphragm surgically plicated during infancy and early childhood. Ann Thorac Surg 1987; 44:62.
  66. Alonso Calderón JL, Garrido García H, Pérez Domínguez T, Mazaira J. [Simultaneous, bilateral and permanent ventilation with a diaphragm pacing in childhood: the implantation technique and indications]. Cir Pediatr 1994; 7:3.
  67. Brouillette RT, Ilbawi MN, Klemka-Walden L, Hunt CE. Stimulus parameters for phrenic nerve pacing in infants and children. Pediatr Pulmonol 1988; 4:33.
  68. Brouillette RT, Marzocchi M. Diaphragm pacing: clinical and experimental results. Biol Neonate 1994; 65:265.
  69. Radecki LL, Tomatis LA. Continuous bilateral electrophrenic pacing in an infant with total diaphragmatic paralysis. J Pediatr 1976; 88:969.
Topic 4990 Version 23.0

References

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟