ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد ایتم قابل مشاهده باقیمانده : 1 مورد
نسخه الکترونیک
medimedia.ir

Gentamicin (topical): Pediatric drug information

Gentamicin (topical): Pediatric drug information
(For additional information see "Gentamicin (topical): Drug information" and see "Gentamicin (topical): Patient drug information")

For abbreviations and symbols that may be used in Lexicomp (show table)
Brand Names: Canada
  • PMS-Gentamicin [DSC]
Therapeutic Category
  • Antibiotic, Aminoglycoside;
  • Antibiotic, Topical
Dosing: Pediatric

Dermatologic infections: Infants, Children, and Adolescents: Topical: Cream, Ointment: Apply 3 to 4 times/day to affected area (Bradley 2017)

Dosing: Renal Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Adult

(For additional information see "Gentamicin (topical): Drug information")

Dermatologic infections: Topical: Apply 3 to 4 times daily to affected area

Dosing: Renal Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External:

Generic: 0.1% (15 g, 30 g)

Ointment, External:

Generic: 0.1% (15 g, 30 g)

Generic Equivalent Available: US

Yes

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Generic: 0.1% ([DSC])

Ointment, External:

Generic: 0.1% ([DSC])

Administration: Pediatric

For external topical use only; not for ophthalmic use. Apply a small amount gently to the cleansed affected area; may cover with gauze dressing.

Administration: Adult

For external use only; not for ophthalmic use. Apply gently to affected area; may cover with gauze dressing.

Storage/Stability

Store at controlled room temperature of 20°C to 25°C (68°F to 77°F).

Use

Topical treatment of superficial infections of the skin including folliculitis, impetigo contagiosa, furunculosis, sycosis barbae, ecthyma, pyoderma gangrenosum, infectious eczematoid dermatitis, pustular acne, pustular psoriasis, infected seborrheic dermatitis or contact dermatitis, infected excoriations and bacterial super-infections of fungal or viral infections (FDA approved for ages >1 year and adults)

Medication Safety Issues
Sound-alike/look-alike issues:

Gentamicin may be confused with gentian violet, kanamycin, vancomycin

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.

Dermatologic: Erythema, pruritus

Contraindications

Hypersensitivity to gentamicin or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Superinfection: Prolonged use may result in fungal or bacterial superinfection; discontinue if superinfection is noted.

• Sensitization: Topical use has been associated with local sensitization (redness, irritation); discontinue if sensitization is noted.

Other warnings/precautions:

• Long-term use: Not intended for long-term therapy.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Mechanism of Action

Interferes with bacterial protein synthesis by binding to 30S ribosomal subunit resulting in a defective bacterial cell membrane

Pharmacokinetics (Adult data unless noted)

Absorption: Systemic absorption is reported following topical application to burn patients (Sawchuk 1980).

Pricing: US

Cream (Gentamicin Sulfate External)

0.1% (per gram): $1.00 - $3.29

Ointment (Gentamicin Sulfate External)

0.1% (per gram): $3.29

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Brand Names: International
  • Alexgenta (EG);
  • Bioderm (ID);
  • Cidomycin (EG);
  • Gamicin (TW);
  • Garalone (PT);
  • Garamicina (CR, DO, GT, HN, NI, PA, SV);
  • Garamycin (AE, CH, CZ, EG, FI, HK, ID, MY, NL, PH, QA, RU, SA, SE, SG, TH, TR, TW, VN);
  • Gentacin (KR);
  • Gentaderm (AR);
  • Gental (AE, BH, EG, KW, QA, SA, TH);
  • Gentalyn (IT, VE);
  • Gentalyn Crema (CL);
  • Gentamerck (ID);
  • Gentamina (PY);
  • Gentatrim (IL);
  • Geomycine (BE);
  • Ikagen (ID);
  • Konigen (ID);
  • Licogenta (ID);
  • Lyramycin (IN, LK);
  • Miragenta (CO);
  • Miramycin (SG, TH);
  • Qutacin (TW);
  • Refobacin (DE);
  • Skinfect (TH);
  • Sulmycin (DE);
  • Versigen (TH)


For country abbreviations used in Lexicomp (show table)

REFERENCES

  1. Bradley JS, Nelson JD, Barnett E, et al. Nelson's Pediatric Antimicrobial Therapy. 23rd ed. American Academy of Pediatrics; 2017.
  2. Gentamicin ointment [prescribing information]. Melville, NY: Fougera Pharmaceuticals Inc.; February 2014.
  3. Gentamicin sulfate cream [prescribing information]. Buena, NJ: Teligent Pharma Inc; March 2021.
  4. Sawchuk RJ, Rector TS. Drug kinetics in burn patients. Clin Pharmacokinet. 1980;5(6):548-556.
Topic 15995 Version 129.0