INTRODUCTION — The third stage of labor is the interval from the birth of the neonate to expulsion of the placenta. Delayed placental separation and expulsion is a potentially life-threatening event because it impedes normal postpartum uterine contraction, which can lead to hemorrhage.
This topic will discuss the diagnosis and management of a retained placenta after vaginal birth. Management of retained products of conception after a miscarriage or pregnancy termination is reviewed separately. (See "Retained products of conception in the first half of pregnancy".)
DEFINITION — Retained placenta can be defined as lack of expulsion of the placenta within 30 minutes of birth of the neonate [1,2]. This is a reasonable definition in the third trimester when the third stage of labor is actively managed (ie, administration of a uterotonic agent before delivery of the placenta, controlled cord traction) because 98 percent of placentas are expelled by 30 minutes in this setting (figure 1) .
Physiologic management of the third stage (ie, delivery of the placenta without the use of uterotonic agents or cord traction) increases the frequency of retained placenta: only 80 percent of placentas are expelled by 30 minutes (figure 1) and it takes approximately 60 minutes before 98 percent of placentas are expelled.
The frequency of retained placenta is 3-fold higher in preterm gestations compared with term gestations, particularly in the second trimester when the risk is 21-fold higher compared with term gestations (figure 2). For gestations at 20 and 30 weeks to achieve a 90 percent spontaneous placental delivery rate, a life-table analysis predicted it would take 180 and 21 minutes, respectively .
These findings suggest that the definition, or the timing of intervention, should take into account how the third stage of labor is managed as well as the gestational age at delivery. In part for these reasons, the World Health Organization concluded that the length of time before making a diagnosis of retained placenta should be "left to the judgement of the clinician" . (See "Management of the third stage of labor: Prophylactic pharmacotherapy to minimize hemorrhage" and 'Indications for intervention' below.)
TYPES OF RETAINED PLACENTA — The three types of retained placenta, in order of increasing morbidity, are (figure 3):
●Trapped or incarcerated placenta – A separated placenta that has detached completely from the uterus, but has not delivered spontaneously or with light cord traction because the cervix has begun to close.
●Placenta adherens – A placenta that is adherent to the uterine wall but is easily separated manually.
●Placenta accreta spectrum – A placenta that is pathologically attached to the myometrium due to defective decidua. It cannot be cleanly separated manually, although the placenta may still be removed vaginally if the abnormal area of attachment is small.
PATHOGENESIS — Ultrasound studies have identified four phases in the third stage of labor . An abnormality in one or more of these phases may be the mechanism for retained placenta:
●Latent phase – Immediately after birth, all of the myometrium contracts except for the portion beneath the placenta.
●Contraction phase – The retroplacental myometrium contracts.
●Detachment phase – Contraction of the retroplacental myometrium produces horizontal (shear) stress on the maternal surface of the placenta, causing it to detach.
●Expulsion phase – Myometrial contractions expel the detached placenta from the uterus.
A trapped placenta may be seen as a failure of the expulsion phase, where the lower uterine segment and cervix contract before the placenta separates, or if expulsive or gravitational forces are inadequate to deliver the placenta.
Placenta adherens may be seen as resulting from a prolonged latent phase and/or abnormal contraction phase . It has been hypothesized that localized failure of myometrial contractility may be present throughout labor and result in both dysfunctional labor and placenta adherens [7-9]. If the localized contractile failure is severe, then protraction or arrest of labor will occur and cesarean birth may be needed. If localized contractile failure is not severe, then the patient may achieve a vaginal birth, but is at increased risk of a placenta adherens. Histologic studies suggest that the underlying mechanism may be placental changes associated with oxidative stress or preeclampsia .
The pathogenesis of placenta accreta is completely different, as it is a structural rather than a functional abnormality. (See "Placenta accreta spectrum: Clinical features, diagnosis, and potential consequences", section on 'Pathogenesis'.)
PREVALENCE — The overall prevalence of retained placenta varies across settings and over time. In a systematic review of observational studies, the median prevalence of retained placenta at 30 minutes in high-resource settings was 2.7 percent of vaginal births compared with 1.5 percent in low-resource settings . The prevalence in the United Kingdom appears to be increasing from 0.5 percent in the 1930s to 2.3 percent in the 1980s  to 3.3 percent in the author's hospital in 2005 to 2006 . The difference in prevalence between the low and high resource countries and over time are probably related to differences in epidemiology and risk factors.
In the author's large prospective audit of cases of retained placenta that were resolved without hysterectomy, trapped placenta, placenta adherens, and placenta accreta accounted for 13, 81, and 6 percent of cases, respectively . In another series, trapped placenta accounted for 51 percent of placentas manually removed to prevent postpartum hemorrhage .
Although small areas of focal placenta accreta are not uncommon at vaginal birth, a complete placenta accreta is rare, as most affected patients give birth by repeat cesarean delivery. These patients typically have a history of previous cesarean birth and placenta previa, which are indications for repeat cesarean birth. We estimate only 1 in 440 patients who have a retained placenta following vaginal birth will have placenta accreta spectrum. (See "Placenta accreta spectrum: Clinical features, diagnosis, and potential consequences".)
RISK FACTORS — A great variety of risk factors have been associated with retained placenta, including [14-16]:
●Previous retained placenta
●Preterm gestational age (figure 2)
●Use of ergometrine
●Previous cesarean birth, curettage, or myomectomy
●Preeclampsia, stillbirth, or small for gestational age neonate
●Velamentous cord insertion
●Maternal age ≥30 years
●Delivery in a teaching hospital
The association between active management of the third stage of labor with ergometrine and a prolonged third stage is likely a peculiarity of ergometrine, which, in contrast to oxytocin, causes a powerful, continuous uterine contraction. With intravenous (IV) administration, the onset of uterine contraction is immediate and closes the cervix at the same time as placental detachment occurs, thus trapping the placenta behind a closed cervix. The only trial to study use of IV ergometrine for management of the third stage of labor found a massive increase in the need for manual removal of the placenta (relative risk 19.5, 95% CI 2.6-145.4) . This finding was supported by data from a population study in Sweden: The retained placenta rate in 10 centers that routinely used methylergometrine was significantly higher than those that used oxytocin alone (2.7 versus 1.8 percent) . It was also found incidentally in the WHO study of controlled cord traction .
Uterine abnormalities appear to be a prominent risk factor. In a series of 63 pregnancies in patients with bicornuate, septate, or arcuate uteri, retained placenta was the predominant complication and occurred in 17 percent . In a study that performed routine hysteroscopy six weeks after manual removal of a retained placenta in 48 patients, 15 percent had an incomplete uterine septum .
A large population-based cohort study found that the rate of retained placenta was increased in patients with a previous cesarean birth compared with those with a previous vaginal birth (3.4 versus 1.9 percent) and the risk was not mediated by an anterior location of the placenta on ultrasound .
Defective placental implantation may be the underlying reason that preeclampsia, stillbirth, and fetal growth restriction/small for gestational age birth weight have been associated with retained placenta .
A velamentous cord insertion is a risk factor and has been described in 5.5 percent of pregnancies with this cord abnormality . Presumably, breakage of the fragile cord at birth resulted in a retained placenta.
CLINICAL FINDINGS AND DIAGNOSIS — We and others make the diagnosis of retained placenta when the placenta has not been expelled within 30 minutes of birth of the neonate. This is an arbitrary definition, which may be modified depending upon the gestational age and management of the third stage. (See 'Definition' above.)
A diagnosis of trapped placenta is made when the classic clinical signs of placental separation are present (lengthening of the umbilical cord, gush of blood from the vagina, change in the shape of the uterine fundus from discoid to globular, elevation of the fundal height, and contraction of the fundus) and the edge of the placenta is palpable through a small but patent cervical os.
A diagnosis of placenta adherens or placenta accreta is made in the absence of signs and symptoms of placental separation. Placenta adherens is generally only clinically distinguishable from placenta accreta at the time of attempted manual removal. If a clean plane of separation can be created between the entire placenta and decidua, the diagnosis is placenta adherens. If areas of myometrial invasion prevent clean separation of part of the placenta, the diagnosis is focal placenta accreta. However, a mild focal placenta accreta can be difficult to distinguish clinically from placenta adherens.
Imaging — Ultrasound can distinguish between a detached trapped placenta and an adherent placenta, but is rarely performed unless the diagnosis is uncertain after physical examination . With a trapped placenta, the myometrium is thickened all around the uterus and the placenta is seen within but largely separate from the uterine body in the lower segment. By contrast, with an adherent placenta the myometrium will be thickened in all areas except where the placenta is attached, where it will be very thin or even invisible (image 1) and no area of the placenta will be separate from the uterine body.
Placental pathology — A case-control study performed macroscopic and histologic analysis of adherens-type retained (n = 49) and nonretained (n = 47) term singleton placentas from otherwise healthy pregnancies (defined as no preeclampsia, diabetes, small for gestational age neonate) . Adherens-type retained placentas had a significantly smaller surface area, were more oblong in shape, and had more signs of maternal underperfusion. They also had more basal plate myometrial fibers but no increase in focal accreta. This is consistent with the association of retained placenta with fetal growth restriction and stillbirth (see 'Risk factors' above) but suggests the association is with adherens-type rather than focal accreta .
COMPLICATIONS — The two most common complications of retained placenta are postpartum hemorrhage and postpartum endometritis. Uterine inversion is less common, but is an obstetric emergency since it can lead to severe hemorrhage and shock if not recognized and treated promptly (see "Puerperal uterine inversion"). The frequency of these complications depends on multiple factors, including the definition used, etiology, and management of the retained placenta.
In high-resource settings, death from retained placenta is very rare. In settings with fewer resources, however, the case fatality rate is commonly around 1 percent, depending upon the patient's ability to access services for treatment and support .
INDICATIONS FOR INTERVENTION
Patients with severe bleeding — Severe bleeding is an obstetric emergency that requires prompt intervention. Bimanual compression is not possible with a retained placenta, but aortic compression may be effective as an emergency measure. (See "Postpartum hemorrhage: Medical and minimally invasive management".)
The retained placenta should be manually removed as soon as possible. Expulsion of the placenta promotes global uterine contraction and will likely reduce bleeding. (See 'Perform manual extraction' below.)
Patients without severe bleeding — When the placenta has been retained for 30 minutes in a stable patient giving birth in the third trimester, we perform a physical examination (and sometimes ultrasound) to determine whether the placenta is merely trapped or still adherent (see 'Clinical findings and diagnosis' above) and begin preparations for intervention (see 'Management' below). The optimum timing of intervention balances the risk (postpartum hemorrhage) of leaving the placenta in situ and the risks of intervention (postpartum hemorrhage and/or infection, uterine trauma) versus the likelihood that the placenta will spontaneously deliver with expectant management.
There is no consensus worldwide as to when intervention is indicated. We suggest discontinuing expectant management at 60 minutes based on data suggesting that delaying intervention until at least 30 minutes have elapsed will lead to spontaneous delivery of many placentas, and the risk of hemorrhage does not begin to increase until 20 to 30 minutes after birth [7,26,27]. Waiting as long as 60 minutes is reasonable if an intervention can be promptly and successfully initiated if the patient begins to bleed excessively. This time period could be extended beyond 60 minutes for deliveries in the second trimester where the frequency of retained placenta is higher (figure 2) and the frequency of hemorrhage is lower. In the second trimester, for most patients, waiting two hours for placental expulsion is reasonable as it maximizes the probability of spontaneous placental delivery and minimizes the risk of complications; however, the timing of intervention should be individualized based upon maternal characteristics and intrapartum conditions . By contrast, some authors have taken a more aggressive approach, suggesting that 15 to 20 minutes may be the optimum duration of expectant management [29-31].
There are very limited data to guide the maximum duration of expectant management [32,33], but we suggest not delaying intervention by more than two hours from birth of the neonate due to the risk of infection and bleeding. In a trial including 51 patients who gave birth in the third trimester with retained placenta at 60 minutes and no pharmacologic intervention, 23 patients (45 percent) eventually expelled the placenta spontaneously, but 24 of the 51 patients (47 percent) bled over 1000 mL and 9 (18 percent) were transfused .
MANAGEMENT — The following steps in the approach to managing a retained placenta are based on our understanding of the etiology, pathophysiology, and complications of this disorder. The World Health Organization has also published an algorithm that describes a typical approach .
Studies of the management of retained placenta have not taken into account the type of retained placenta in their inclusion/exclusion criteria or in outcome data. If effective medical therapies become available in the future, then ultrasound will be important to distinguish the underlying pathology causing placental retention .
Apply controlled cord traction — Gentle controlled cord traction alone may result in successful delivery of a trapped or incarcerated placenta or promote separation of placenta adherens . For the Brandt-Andrews maneuver, one hand is placed on the abdomen to secure the uterine fundus and prevent uterine inversion while the other hand exerts sustained downward traction on the umbilical cord in a direction parallel to the birth canal . Care should be taken to avoid avulsion of the cord.
A pilot study suggested that additional benefit can be gained by applying cord traction perpendicular to the direction of the birth canal while rotating the clamped end of the cord slowly in 360-degree clockwise rotation around the vaginal opening until the placenta is delivered: the "Windmill technique" . Further study to confirm these findings is required.
Manage bleeding — Onset of uterine bleeding with a retained placenta may indicate separation, so it is worthwhile attempting further cord traction if bleeding starts.
If the placenta remains in the uterus despite increased traction, oxytocin should be administered intravenously.
Prostaglandin F2-alpha (carboprost tromethamine) may be of benefit if bleeding is severe and not controlled with oxytocin. Tranexamic acid (1 gram intravenous [IV] injection) is effective for reducing mortality if heavy bleeding persists. The WOMAN study reported a 19 percent reduction in maternal death in 20,060 patients with postpartum hemorrhage; 10 percent of the patients had a retained placenta . Ergometrine should be avoided, if possible, as it constricts the cervix, making manual removal very difficult. Intrauterine balloon tamponade has no role in this situation.
If these measures fail to reduce bleeding, then aortic compression is a useful maneuver to stop pelvic blood flow while the patient's hemodynamic and hemostatic status is evaluated and supported and while arrangements for laparotomy are made. A clinician should check for loss of femoral pulse to confirm that it is being applied effectively. (See "Postpartum hemorrhage: Medical and minimally invasive management", section on 'Consider external aortic compression'.)
Address excessive cervical/uterine contraction — If the lower uterus/cervix is contracted, preventing expulsion of the placenta ("trapped placenta"), administering nitroglycerin may relax smooth muscle in the myometrium and cervix and facilitate manual placental delivery [40-44]. However, randomized trials have shown that it does not reduce the need for manual extraction [45,46].
There are no high-quality data to support a specific recommendation for dose or route of administration. For a tight cervix preventing manual removal, we use nitroglycerin two sprays (400 micrograms/spray) onto or under the tongue. Another option is administration of sequential bolus IV injections: 50 micrograms, may repeat at one minute intervals (maximum cumulative dose of 250 micrograms) until sufficient uterine relaxation is achieved to allow manual removal of the placenta. A third option is sublingual tablets 0.6 to 1 milligrams. Uterine relaxation occurs within 60 seconds after the dose and lasts for one to two minutes.
Blood pressure should be monitored continuously as a drop in blood pressure always occurs, although most patients do not become hypotensive. Using sequential boluses and monitoring maternal blood pressure help to minimize the occurrence of severe hypotension. Headache is a common side effect.
Perform manual extraction — Manual extraction of the placenta is performed if controlled cord traction and drug therapy (when indicated as described above) do not lead to delivery of the retained placenta. Manual extraction is painful; therefore, except in cases of severe bleeding or other emergency, adequate analgesia should be achieved with regional or general anesthesia or procedural sedation and analgesia (formerly termed conscious sedation). The procedure should be performed in a room where aseptic technique is easily achieved and appropriate personnel, medications, and equipment are available to deal with any complications (eg, hemorrhage, placenta accreta, uterine perforation) that arise.
Manual extraction of the placenta increases the risk of endometritis [47,48]. For this reason, we agree with the World Health Organization recommendation to administer prophylactic antibiotics , although there are no data to support or refute this practice . We administer a single dose of a broad spectrum antibiotic (eg, ampicillin or a first-generation cephalosporin; clindamycin if penicillin allergy).
After routine surgical preparation and bladder catheterization, one hand follows the path of the umbilical cord through the vagina, cervix, and lower uterine segment to find the maternal-placental interface, while the other hand is placed on the mother's abdomen and used to maintain the uterine fundus in position. If the opening of the cervix is too small to admit the clinician's hand, uterine relaxation may be achieved with nitroglycerin (see 'Address excessive cervical/uterine contraction' above). The plane of interface, which feels velvety and irregular, is gently dissected using a side-to-side motion of the fingers until the placenta has been completely separated.
We believe there is no role for routine uterine curettage or aspiration after manual extraction. It has no documented benefit and carries the risk of uterine perforation and Asherman syndrome. Routine ultrasound evaluation of the uterus after manual extraction is also unnecessary .
Management of refractory or complicated cases
Instrument extraction — If digital extraction is not possible, a large-headed forceps (eg, Bierer forceps, ring forceps) can be used to grip and extract the placenta in pieces or as an intact specimen; ultrasound guidance can be helpful. One group described grasping the placental tissue with Bierer forceps under ultrasound guidance and applying slow, gentle traction in short strokes, regrasping increasingly more distal areas of placenta, as needed, to gently extract the placenta . This procedure requires less analgesia than digital extraction.
The placenta and the uterus should be examined after extraction to ensure that the placenta was completely removed.
Incomplete extraction — During manual placental extraction, the clinician may note a small area where the placenta is very adherent to the uterus. This can usually be managed by slow persistent finger dissection to create a plane of separation at the maternal-placental interface. The plane of dissection is often partially through the placenta in these cases, which leaves some placenta adherent to the decidua and myometrium. This will not lead to postpartum hemorrhage as long as the uterus contracts well and there is no area of subinvolution at the site of the retained placental fragments. Curettage should be avoided, if possible, as the myometrium may be very thin at the point of adherence, thus increasing the risk of perforation. Curettage of the postpartum uterus also increases the risk of formation of intrauterine adhesions (Asherman syndrome).
However, if placental tissue is retained and the patient is bleeding excessively, then curettage using a large blunt placental curette or aspiration is reasonable to remove the remaining placental tissue. Incomplete extraction may result in secondary postpartum hemorrhage (ie, significant uterine bleeding occurring between 24 hours and 12 weeks postpartum). Diagnosis and management of late postpartum hemorrhage are reviewed separately. (See "Secondary (late) postpartum hemorrhage".)
Occasionally, following either spontaneous or manual placental delivery, a placental pathology report will question the completeness of the placenta. If the placenta was disrupted and the fragments sent to pathology, it is difficult for the pathologist to determine whether there may be additional retained placenta based only on the weight and appearance of the placental fragments. In this situation, clinical assessment and uterine ultrasound can assist to determine whether any tissue is retained. Echogenic material is commonly found in the postpartum uterus, especially in the second and third weeks postpartum, and should not be assumed to be retained placental tissue. The finding of calcification or low-resistance color Doppler flow within an intrauterine mass is suggestive of retained placenta, while a thin endometrial thickness excludes it . Expectant management is reasonable in an asymptomatic patient with a nonvascular intrauterine mass. (See "Overview of the postpartum period: Normal physiology and routine maternal care", section on 'Findings on ultrasound'.)
Unexpected placenta accreta spectrum — Rarely, the placenta accreta spectrum is first recognized at the time of manual removal of the placenta. In these cases, there is no plane of dissection between the uterus and placenta and, almost invariably, attempts at manual removal lead to life-threatening hemorrhage. We suggest administration of uterotonic drugs and preparation for hysterectomy, which is the definitive therapy. (See "Placenta accreta spectrum: Management".)
Inefffective or unproven interventions — After routine management of the third stage, there is no strong evidence that additional systemic or intraumbilical vein pharmacotherapy reduces the need for manual removal of a retained placenta.
●Systemic administration – It has been hypothesized that administration of an additional intravenous, intramuscular, or oral uterotonic drug may facilitate separation of a retained placenta, in part because placenta adherens appears to result from contractile failure in the retroplacental area. However, very few studies have addressed this issue. In a meta-analysis of 29 randomized trials of pharmacologic intervention by various routes for the management of retained placenta, only six trials examined systemic administration (methylergometrine, carbetocin, sulprostone, nitroglycerin, misoprostol) and the remainder involved intraumbilical injections . Only the trial comparing intravenous sulprostone (prostaglandin E2) with intravenous placebo found a benefit (49 percent reduction in the need for manual removal) . When the same team repeated the study with larger numbers and compared sublingual misoprostol with placebo, there was no difference in need for manual removal .
●Intraumbilical vein injection – In a meta-analysis of placebo-controlled randomized trials of umbilical vein oxytocin, the intervention did not result in a clear or substantial reduction in need for manual removal of retained placenta compared with saline injection, although a small reduction was possible (eg, frequency of manual placental removal: 513 versus 626 per 1000; RR 0.82, 95% CI 0.69-0.97; 14 trials, 1370 participants; low-quality evidence) . There was also no significant effect on blood loss outcomes (≥500 mLs or mean blood loss). The World Health Organization (WHO) now only recommends use of umbilical vein oxytocin for management of retained placenta in the context of randomized trials and in the absence of abnormal bleeding .
Data from five small trials on the use of intra-umbilical injection of dissolved misoprostol suggested some benefit; more robust studies are awaited . (See "Management of the third stage of labor: Prophylactic pharmacotherapy to minimize hemorrhage".)
PREVENTION — There are few trials of techniques for the prevention of retained placenta, and no intervention has been proven to be effective. In systematic reviews of randomized trials, the frequency of retained placenta was not reduced by use of oxytocin for active management of the third stage of labor, timing of oxytocin administration (before versus after placental expulsion), or early versus delayed cord clamping [59,60]. Cord drainage during the third stage reduced the frequency of retained placenta at 30 minutes (relative risk 0.28, 95% CI 0.10-0.73, one trial, 477 participants) , but this finding is not consistent with the finding from trials of late cord clamping , which would also have the effect of placental drainage.
RECURRENCE RISK — Following a retained placenta in any previous pregnancy, the odds of recurrence were 12.6 (95% CI 3.6-44.1) in one study . In other studies, the absolute risk of recurrent retained placenta was 6.25 percent  and the absolute risk of recurrent manual removal of the placenta was 17 percent .
SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Delivery".)
SUMMARY AND RECOMMENDATIONS
●Definition – Retained placenta can be defined as lack of placental expulsion within 30 minutes of delivery of an infant. This time period can be extended to 90 to 120 minutes in the absence of hemorrhage for births in the second trimester and third stages of labor managed without oxytocin. (See 'Definition' above.)
●Etiology – The three etiologies of retained placenta are: the placenta may be trapped behind a partially closed cervix (trapped or incarcerated placenta); the placenta may be adherent to the uterine wall, but easily separated manually (placenta adherens); or the placenta may be pathologically invading the myometrium (placenta accreta) (figure 3). (See 'Types of retained placenta' above.)
●Clinical findings and diagnosis – A diagnosis of trapped placenta is made when the classic clinical signs of placental separation are present (lengthening of the umbilical cord, gush of blood from the vagina, change in the shape of the uterine fundus from discoid to globular, elevation of the fundal height, and contraction of the fundus) and the edge of the placenta is palpable through a narrow cervical os.
A diagnosis of placenta adherens or placenta accreta is made in the absence of signs and symptoms of placental separation. Placenta adherens is indistinguishable from placenta accreta until the time of attempted manual removal. If a clean plane of separation can be created between the entire placenta and decidua, the diagnosis is placenta adherens. If areas of myometrial invasion prevent clean separation of part of the placenta, the diagnosis is focal placenta accreta. (See 'Clinical findings and diagnosis' above.)
●Complications – Postpartum hemorrhage is the major complication of retained placenta. (See 'Complications' above.)
•Patients with severe bleeding – Severe bleeding is an obstetric emergency that requires prompt intervention. The retained placenta should be manually removed as soon as possible. (See 'Patients with severe bleeding' above.)
•Patients giving birth in the third trimester without severe bleeding – In the absence of heavy bleeding, in the third trimester we suggest intervention when the placenta has been retained for 30 to 60 minutes rather than expectant management or earlier intervention (Grade 2C). (See 'Patients without severe bleeding' above.)
-Gentle cord traction is the initial maneuver. If the uterus is atonic, we administer an oxytocin infusion to promote uterine contraction. If these measures fail to result in placental expulsion, we suggest manual rather than instrumental extraction of the placenta (Grade 2C). If a tight restriction ring prevents entry of the hand into the uterus, nitroglycerin spray or tablets may be helpful. (See 'Management' above.)
•Patients giving birth in the second trimester without severe bleeding – For patients with a second-trimester birth and no significant bleeding, the time period before manual extraction can be extended as the frequency of retained placenta is higher and the risk of hemorrhage is lower. We suggest not waiting more than two hours due to the risk of infection (Grade 2C). (See 'Management' above.)
•Patients with focal accreta – For patients with a small area of placenta accreta, we slowly create a plane of separation at the maternal-placental interface using finger dissection. Curettage is a second-line option if finger dissection is unsuccessful. (See 'Unexpected placenta accreta spectrum' above.)