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Contribution of carcinogenic HPV genotypes and CIN 3+ progression risk for progression to CIN grade 3 or worse

Contribution of carcinogenic HPV genotypes and CIN 3+ progression risk for progression to CIN grade 3 or worse
Carcinogenic HPV type Percent of cervical cancers 9-year risk of progression to CIN3+ of incident HPV infection Risk group
16 60.3 6.3 16
18 10.5 3.0 18/45
45 6.1 2.2 18/45
33 3.7 4.5 16-related
31 3.6 2.2 16-related
52 2.7 2.2 16-related
58 2.2 1.9 16-related
35 2.0 2.8 16-related
39 1.6 1.1 Other
51 1.2 1.1 Other
59 1.1 0.9 Other
56 0.9 0.8 Other
68 0.6 1.0 Other
This table summarizes the proportion of cancers caused by 13 HPV types and the risk of progression from infection to CIN 3+.
CIN: cervical intraepithelial neoplasia; HPV: human papillomavirus.
Reproduced with permission from: Wolters Kluwer Health, Inc.: Massad LS, Clarke MA, Perkins RB, et al. Applying results of extended genotyping to management of positive cervicovaginal human papillomavirus test results: Enduring guidelines. J Low Genit Tract Dis 2025; 29(2):134-143. Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Society for Colposcopy and Cervical Pathology. https://journals.lww.com/jlgtd/pages/default.aspx.
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