Version July 2025
| Drug | Dose | Onset | Half-life | Platelet recovery time |
| Oral agents | ||||
| Aspirin (nonenteric coated tablet) | 325 mg orally once |
| 20 minutes | 5 to 7 days, lifetime of platelet |
| Clopidogrel | 300 to 600 mg orally once | 2 to 6 hours | 6 to 8 hours (prodrug and inactive metabolite) | 5 to 7 days, lifetime of platelet |
| Ticagrelor | 180 mg orally once | 30 minutes to 2 hours | 7 hours (parent drug); 9 hours (active metabolite) | 3 to 5 days |
| Intravenous agents | ||||
| Tirofiban | 12 mcg/kg IV bolus over 30 minutes, followed by 0.1 mcg/kg/minute (decrease infusion dose by 50% in patients with moderate to severe kidney dysfunction) | <10 minutes | 1 to 2 hours | 4 to 8 hours |
| Eptifibatide | 90 to 180 mcg/kg IV bolus over ≤5 minutes, followed by 0.25 to 1 mcg/kg/minute (decrease infusion dose by 50% in patients with moderate to severe kidney dysfunction) | 30 minutes | 1 to 2 hours | 4 to 8 hours |
| Cangrelor | 30 mcg/kg IV bolus over <1 minute, followed by 1 to 4 mcg/kg/minute | Immediate | 3 to 5 minutes | 1 hour |
