Indications for endoscopic resection of early gastric cancer
Indications for endoscopic resection of early gastric cancer
Absolute indications (all of the following):
Histology: Differentiated
Size: ≤20 mm
Ulceration: None
Tumor type: Intestinal
No suspected lymphovascular invasion
Expanded indications (any of the following):
Mucosal tumors >30 mm, differentiated type, and without ulceration
Mucosal tumors <30 mm in size, differentiated type, with ulceration
Mucosal tumors ≤20 mm, undifferentiated type, without ulceration
Submucosal tumors <30 mm invading less than 500 micrometer into the submucosa without lymphovascular invasion
The absolute indication for endoscopic resection originated from identifying risk factors for lymph node metastases, which were determined after evaluating surgically resected specimens. Use of the expanded criteria for curative endoscopic management remains investigational. Patients with tumors that do not have absolute indications, but who cannot undergo surgery because of comorbidities, have relative indications for endoscopic resection.
References:
Ono H, Yao K, Fujishiro M, et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition). Dig Endosc 2021; 33:4.
Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer 2000; 3:219.
NCCN Clinical Practice Guidelines in Oncology: Gastric cancer https://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf (Accessed on 5/2/2024).