Version June 2024
| Drug | Vd | pKa | Protein binding | Half-life (parent drug, unless noted)* |
| Long-acting (>6 hours) | ||||
| Phenobarbital | 0.6 L/kg | 7.3 | 48% | 70 to 140 hours |
| Primidone | 0.6 to 0.75 L/kg | 12.3 | <20% | Parent drug: 5 to 16 hours Active metabolites:
|
| Intermediate-acting (2 to 6 hours) | ||||
| Amobarbital | 1 L/kg | 7.84 | 40 to 60% | 16 to 40 hours |
| Butalbital¶ | 0.8 L/kg | 7.48 | 45% | 35 to 88 hours |
| Short-acting (<2 hours) | ||||
| Methohexital | 1.1 L/kg | 7.73 | 73% | 1.6 to 3.9 hours |
| Pentobarbital | 1 L/kg | 8.1 | 45 to 70% | 15 to 50 hours |
| Thiopental | 4.4 L/kg | 7.55 | 80% | 9 to 11 hours |
* The duration of clinical effect does not always correspond to the elimination half-life, but rather to rate of redistribution from the central nervous system. Highly lipid soluble and highly protein bound barbiturates (eg, thiopental, methohexital) redistribute quickly and have a short duration of effect despite long terminal elimination half-lives. Less lipid-soluble drugs with lower protein binding (eg, phenobarbital) have longer durations of effect.
¶ Butalbital is available in multi-ingredient preparations (ie, co-formulated with acetaminophen, aspirin, caffeine, and/or codeine).آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
