Calculator: Glomerular filtration rate estimation (eGFR) by CKD-EPI equation with cystatin C, in adults, without race (2012)

Input

Sex	Female
	Male
Age
Cystatin C
Optional parameters to calculate patient-specific eGFR based on patient's body surface area (BSA)
Height
Weight

Results

Important: Inputs must be complete to perform calculation.


eGFR normalized to a BSA of 1.73 m²
eGFR		mL/min/1.73 m²
eGFR without normalization to BSA
BSA		m²
eGFR for this BSA

Decimal precision

Notes

The default units of measure for weight and height are kilograms and centimeters. Please verify that the correct unit of measure has been selected.
eGFR is calculated by equations developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI).
Calculated eGFR results are rounded to the nearest integer. There may be significant differences between estimated and measured GFR on an individual patient level.[5]
eGFR without normalization to BSA may be used for purposes of adjustments in medication dosing. Note that using non-normalized eGFR in patients with obesity can result in overestimation of GFR and potential overdosing.
More information on the use of serum cystatin C for estimation of GFR may be found in UpToDate topic reviews that discuss the assessment of kidney function and the staging of chronic kidney disease.

Equations used

eGFR = 133 * min(Cystatin_C/0.8, 1)^-0.499 * max(Cystatin_C/0.8, 1)^-1.328 * 0.996^Age * SexFactor

BSA = 0.007184 * Height^0.725 * Weight^0.425

eGFR for this BSA = eGFR * BSA / 1.73

Calculation details and variables

For females, SexFactor = 0.932; for males, SexFactor = 1.
The min function returns the minimum of the 2 arguments within the parentheses. The max function returns the maximum of the 2 arguments within the parentheses.

References

Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 2012; 367:20.
Inker LA, Eneanya ND, Coresh J, et al. Chronic Kidney Disease Epidemiology Collaboration. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med 2021; 385:1737.
Levey AS, Titan SM, Powe NR, et al. Kidney Disease, Race, and GFR Estimation. Clin J Am Soc Nephrol 2020; 15:1203.
Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916; 17:863-871.
Shafi T, Zhu X, Lirette ST, et al. Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation : A Cross-Sectional Study. Ann Intern Med 2022; 175:1073.

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

Topic 143562 Version 2.0

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Calculator: Glomerular filtration rate estimation (eGFR) by CKD-EPI equation with cystatin C, in adults, without race (2012)