Version May 2024
Pain relief: Topical:
Cream: Apply to the affected area 3 to 4 times daily.
Patch: Apply 1 patch to affected area not more than 3 to 4 times daily; leave in place for no more than 8 hours.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
There are no adverse reactions listed in the manufacturer’s labeling.
OTC labeling: When used for self-medication, do not use if allergic to aspirin, camphor, menthol, methyl salicylate, or any component of the formulation.
Concerns related to adverse effects:
• Burns: May cause serious burns (eg, first- to third-degree chemical burns) at the application site. In some cases, hospitalization has been required. Discontinue use and seek medical attention if signs of skin injury (eg, pain, swelling, blistering) occur following application (FDA Drug Safety Communication 2012).
Special populations:
• Pediatric: The American Academy of Pediatrics suggests that camphor be avoided in pediatric patients because of its lack of efficacy and the well-documented toxicity that may occur with use (AAP 1994). Although toxicity most often results from oral ingestion of topical or inhalation products, combined dermal and inhalation exposure has resulted in toxicity (Love 2004).
Dosage form specific issues:
• Cream: Do not use tight bandages on the treated area.
• Topical patch: Self-medication (OTC use): For external use only and should not be applied to wounds or damaged skin; do not use concurrently with other topical analgesics. Do not use tight bandages on the treated area. Do not use with a heating pad.
Other warnings/precautions:
• Self-medication (OTC use): When used for self-medication, contact health care provider if allergic to aspirin or salicylates prior to use. Discontinue use and contact health care provider if symptoms persist >7 days, condition worsens or recurs, or if rash, irritation, or itching develops. Do not use on open wounds, damaged skin, or rashes; in the eyes or on any mucous membranes.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External:
Bengay Ultra Strength: Camphor 4%, menthol 10%, and methyl salicylate 30% (113 g) [contains edetate (edta) disodium, polysorbate 80, trolamine (triethanolamine)]
GoodSense Muscle Rub: Camphor 4%, menthol 10%, and methyl salicylate 30% (113 g) [contains cetyl alcohol, methylparaben, propylparaben, trolamine (triethanolamine)]
Menticam: Camphor 4%, menthol 7.5%, and methyl salicylate 10% (85 g) [contains cetearyl alcohol, cetyl alcohol, edetate (edta) sodium (tetrasodium), propylene glycol]
Gel, External:
Menticam: Camphor 4%, menthol 10%, methyl salicylate 30% (100 g) [contains benzyl alcohol, polysorbate 80, trolamine (triethanolamine)]
Patch, External:
Asperflex Advance: Camphor 3.1%, menthol 6%, and methyl salicylate 10% (6 ea) [contains edetate (edta) disodium, propylene glycol]
MCM: Camphor 96 mg, menthol 76.8 mg, and methyl salicylate 57.6 mg (5 ea) [contains edetate (edta) disodium, methylparaben, polysorbate 80]
Salonpas: Camphor 3.1%, menthol 6%, and methyl salicylate 10% (6 ea, 20 ea, 60 ea) [latex free]
May be product dependent
Cream (Menticam External)
4-7.5-10% (per gram): $11.71
Gel (Menticam External)
4-10-30% (per gram): $9.95
Patch (Asperflex Advance External)
3.1-6-10% (per each): $0.62
Patch (Salonpas External)
3.1-6-10% (per each): $0.29
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: Apply topically; for external use only. Do not apply to eyes, wounds, rashes, damaged skin, or mucous membranes. Do not bandage treated area tightly.
Topical patch: Apply patch externally to clean and dry affected area. Backing film should be removed prior to application. Do not use a heating pad after application or expose treated area to direct sunlight. Do not use concurrently with other topical analgesics.
Pain relief: Temporary relief of minor aches and pains of muscles and joints associated with arthritis, bruises, simple backache, sprains, and strains.
KIDs List: Camphor, when used in pediatric patients <18 years of age, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of seizures (weak recommendation; low quality of evidence) (PPA [Meyers 2020]).
KIDs List: Salicylates, when used in pediatric patients <18 years of age with suspicion of viral illness (influenza, chickenpox), are identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of Reye syndrome (weak recommendation; very low quality of evidence) (PPA [Meyers 2020]).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Warfarin: Menthol may decrease the serum concentration of Warfarin. Risk C: Monitor therapy
Refer to individual monographs.
Refer to individual monographs.
Camphor: Rubefacient and mild analgesic.
Menthol: Dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect; relieves itching.
Methyl salicylates: Decreases inflammation and an analgesic.
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