MRI of juvenile Huntington disease

11-year-old with juvenile Huntington disease. On FLAIR MRI (A) at age 7 years, there is mild atrophy and hyperintense signal in both the caudate head (arrowheads) and putamen (arrows). 4 years later, FLAIR (B) and coronal T2-weighted MRI with fat saturation (C) show progressive atrophy of the corpus striatum and a "box-like" shape of both frontal horns (asterisks) due to caudate head atrophy.