Eye-of-the-tiger sign on MRI

11-year-old child with gait disturbance and dystonia. T2-weighted (A), FLAIR (B), and T2*-weighted gradient echo (C) MRI demonstrating the "eye-of-the-tiger" sign, generated by focal T2 hyperintensity (arrowheads), possibly from tissue necrosis and edema, within the T2-hypointense globus pallidus (arrows). Hypointensity is caused by excessive iron deposition. This patient was confirmed to have neurodegeneration with brain iron accumulation (NBIA) caused by biallelic pathogenic variants in the pantothenate kinase 2 (PANK2) gene.