TXA plasma concentration after different dosing strategies

Tranexamic acid (TXA) plasma concentration measured after administration of different dose schemes in adults and pediatrics.

High dose: 30 mg/kg loading dose, 2 mg/kg in cardiopulmonary bypass (CPB), and 16 mg/kg^–1 h^–1.
Low dose: 10 mg/kg loading dose, 1 mg/kg in CPB, and 1 mg/kg^–1 h^–1.
Continuous: 10 mg/kg loading dose, 10 mg/kg in CPB, and 1 mg/kg^–1 h^–1.
Discontinuous: 10 mg/kg loading dose, 10 mg/kg in CPB, and 10 mg/kg at the end of CPB.

Reproduced with permission from: Koster A, Faraoni D, Levy JH. Antifibrinolytic therapy for cardiac surgery: An update. Anesthesiology 2015; 123(1):214-21. Copyright © 2015 American Society of Anesthesiologists, Inc. and Wolters Kluwer Health, Inc. pubs.asahq.org/anesthesiology.

References:

Grassin-Delyle S, Couturier R, Abe E, et al. A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology 2013; 118:853.
Bojko B, Vuckovic D, Mirnaghi F, et al. Therapeutic monitoring of tranexamic acid concentration: High-throughput analysis with solid-phase microextraction. Ther Drug Monit 2012; 34:31.
Grassin-Delyle S, Tremey B, Abe E, et al. Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth 2013; 111:916.

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TXA plasma concentration after different dosing strategies