Predicted risk of neurodevelopmental sequelae after first-trimester maternal primary CMV infection according to amniocentesis result

Outcome rates calculated for maternal primary infection in any trimester. Symptoms at birth included CNS and non-CNS anomalies on postnatal imaging, elevated liver enzymes, thrombocytopenia, and/or microcephaly.

CMV: cytomegalovirus; AF: amniotic fluid; PCR: polymerase chain reaction; CNS: central nervous system; SNHL: sensorineural hearing loss; US: ultrasound; MRI: magnetic resonance imaging.

* Outcome rates calculated for maternal primary infection at any trimester. Symptoms at birth included CNS and non-CNS anomalies on postnatal imaging, elevated liver enzymes, thrombocytopenia, microcephaly.

References:

Chatzakis C, Ville Y, Makrydimas G, et al. Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences. Am J Obstet Gynecol 2020; 223:870.
Chatzakis C, Sotiriadis A, Dinas K, Ville Y. Neonatal and long-term outcomes of infants with congenital cytomegalovirus infection and negative amniocentesis: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2023; 61:158.
Buca D, Di Mascio D, Rizzo G, et al. Outcome of fetuses with congenital cytomegalovirus infection and normal ultrasound at diagnosis: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2021; 57:551.

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خرید پکیج

Predicted risk of neurodevelopmental sequelae after first-trimester maternal primary CMV infection according to amniocentesis result