Simplified overview of indications for beta cell replacement therapy in people with type 1 diabetes

The two main forms of beta cell replacement therapy are whole pancreas transplantation or islet cell transplantation. Beta cell replacement therapy can be combined with kidney transplantation if the individual has end-stage kidney disease, which may be performed simultaneously or after kidney transplantation. All decisions about transplantation must balance the surgical risk, metabolic need, and the choice of the individual with diabetes.