Indication | Type of heparin | Dosing information |
VTE prevention | LMW heparin | Low dose (also called prophylactic dose):
|
Intermediate dose*:
| ||
UFH | According to trimester¶:
| |
VTE treatment (therapeutic dose) | LMW heparin | Enoxaparin 1 mg/kg SUBQ every 12 hours or Dalteparin 100 units/kg SUBQ every 12 hours |
UFH | Can be given as a continuous IV infusion or SUBQ dose every 12 hours. Titrated to keep the aPTT in the therapeutic range. |
This table applies to VTE in pregnant individuals, with the exception of individuals with a prosthetic heart valve, which is discussed separately in UpToDate.
Refer to UpToDate for anticoagulation indications, choice of dose level, duration of pharmacologic therapy, and timing of switches between LMW heparin and UFH.
ACCP: American College of Chest Physicians; ACOG: American College of Obstetricians and Gynecologists; aPTT: activated partial thromboplastin time; CrCl: creatinine clearance; IV: intravenous; LMW: low molecular weight; SUBQ: subcutaneously; UFH: unfractionated heparin; VTE: venous thromboembolism.
* Our "intermediate" dose level differs from that used in society guidelines (eg, ACCP, ACOG). Some clinicians prefer to use a different "intermediate" dose level such as enoxaparin 40 mg SUBQ every 12 hours; however, this entails a significant increase in the number of injections over the course of the pregnancy.
¶ Some clinicians use 5000 units SUBQ every 12 hours throughout the pregnancy; however, this dose may be insufficient in some patients.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟