Central nervous system management of pediatric acute lymphoblastic leukemia/lymphoblastic lymphoma

This algorithm should be used in conjunction with related UpToDate topics. A diagnostic LP should be performed before or at the beginning of ALL/LBL treatment, whenever possible. Stratification of ALL/LBL risk and details of systemic and CNS-directed therapy vary among treatment groups and should be guided by the chosen treatment protocol. CNS management is administered through all phases of treatment. Patients with evidence of CNS involvement, based on neurologic findings or imaging results should be managed as per CNS 3. RT is generally not given, except for patients with CNS 3 status.