Evaluation of erythrocytosis in adults

This algorithm should be used in conjunction with related UpToDate topics, which also discuss evaluation for cardiopulmonary, renal, and other causes of erythrocytosis.

BM: bone marrow; CBC: complete blood count; EPO: erythropoietin; Hct: hematocrit; Hgb: hemoglobin; MPN: myeloproliferative neoplasm.

* Erythrocytosis: Hgb >16.5 g/dL/Hct >49% in euvolemic men or Hgb >16 g/dL/Hct >48% in euvolemic women.

¶ Test for exon 14 and exon 12 mutations; variant allele frequency >1% is considered positive.

Graphic 140141 Version 1.0

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