Factors associated with increased risk of rebound hyperbilirubinemia after discontinuing phototherapy in term and late preterm newborns

This table summarizes key factors that are associated with increased risk of rebound hyperbilirubinemia after discontinuing phototherapy. Rebound hyperbilirubinemia is defined as a TSB level that reaches the phototherapy threshold within 72 to 96 hours of discontinuing phototherapy. These risk factors are used to guide decisions regarding the timing of phototherapy discontinuation. The usual duration of phototherapy is approximately 24 to 48 hours. Newborns with hemolytic conditions or severe bilirubin elimination disorders may have a more prolonged need for phototherapy. Refer to separate UpToDate content on management of neonatal hyperbilirubinemia for additional details.