A1C over time in type 2 diabetes

Mean A1C levels in patients with type 2 diabetes on metformin monotherapy who were randomly assigned to add-on treatment with sitagliptin (red line), glimepiride (orange line), liraglutide (blue line), or glargine (black line).

A1C: glycated hemoglobin.

From: The GRADE Study Research Group. Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes. N Engl J Med 2022; 387:1063. Copyright © 2022 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.

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A1C over time in type 2 diabetes