Aplastic anemia: Management in adults

This algorithm should be used together with related UpToDate topics for diagnosis and grading of disease severity, assessment of medical fitness, and management of AA in adults.

AA: aplastic anemia; ATG: anti-thymocyte globulin; CsA: cyclosporine A; ECOG PS: Eastern Cooperative Oncology Group performance status; HCT: hematopoietic cell transplantation; TPO: thrombopoietin.

* Criteria for severe AA may vary among centers. Some patients who do not strictly meet these criteria may be considered to have severe AA.

¶ Patients with moderate AA should be monitored for progression to severe AA; treatment is individualized and management should consider comorbid conditions.

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