ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

AFIP prognostic model: Recurrence risk for gastrointestinal stromal tumors (GISTs) of the stomach, small intestine, and rectum by mitotic rate and tumor size

AFIP prognostic model: Recurrence risk for gastrointestinal stromal tumors (GISTs) of the stomach, small intestine, and rectum by mitotic rate and tumor size
Tumor size (cm) Risk of disease progression during long-term follow-up by primary site
Gastric Jejunum/ileum* Duodenum Rectum
Mitotic rate (HPF): ≤5/50
≤2 No risk No risk No risk No risk
2 to 5 Very low Low Low Low
5 to 10 Low Intermediate Limited data Limited data
>10 Intermediate High High High
Mitotic rate (HPF): >5/50
≤2 No riskΔ HighΔ Limited data High
2 to 5 Intermediate High High High
>5 High High High◊ High◊
Based on long-term follow-up studies on 1055 gastric, 629 small intestinal, 144 duodenal, and 111 rectal cancers.

AFIP: Armed Forces Institute of Pathology; HPF: high-power fields.

* Patients with other anatomic primary sites (esophagus, mesentery, peritoneum) or those with limited data follow the risk stratification of jejunum/ileum tumors.

¶ Mitotic rate is counted in an area of 5 square millimeters (mm2) on the glass slide section. For older microscopes with traditional field size optics, 50 HPF is equivalent to 5 mm2. For modern microscopes with wider 40× lenses/fields, 20 HPF is equivalent to 5 mm2. If necessary, the field of view should be measured to determine the actual number of HPF required to cover a 5 mm2 area.[1]

Δ Small number of cases.

◊ Data are combined for tumors >5 cm. There are limited data for duodenal and rectal tumors between 5 and 10 cm in size.
Reference:
  1. Rubin BP, Blanke CD, Demetri GD, et al. Protocol for the examination of specimens from patients with gastrointestinal stromal tumor (GIST): Based on AJCC/UICC TNM, 7th edition, College of American Pathologists (CAP), Washington 2013.

Adapted from: Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006; 23:70.

Graphic 139776 Version 4.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟