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Commonly available nonhormonal vaginal moisturizers formulations

Commonly available nonhormonal vaginal moisturizers formulations
Product Ingredients pH[1,2] Osmolality
(mOSm/kg)[1,2]		 Formulation and use Approximate price
RepHresh Vaginal gel Purified water USP, glycerin, polycarbophil, carbopol 974P, ethylparaben sodium, methylparaben sodium, propylparaben sodium, sodium hydroxide 3.4 1439 to 1914 Prefilled applicator used every 3 days 4 applicators (12 days) $26.49
Replens Long-Lasting Vaginal Moisturizer Purified water, glycerin, mineral oil, polycarbophil, carbomer homopolymer type B, hydrogenated palm oil glyceride, sorbic acid, sodium hydroxide 2.95 to 3.0 1177 to 2011 Prefilled applicator used every 3 days 8 applicators (1-month supply) $22.49
Luvena Water, propanediol, PEG-20, xanthan gum, PEG-20M, simmonsia chinensis (Jojoba) seed oil, vaccinium macrocopon (cranberry) fruit extract, lysozyme, lactoferrin, lactoperoxidase, lactic acid, potassium thiocynanate, glycogen, mannose, tocopherol (vitamin E) Unavailable Unavailable Prefilled applicators, use every 3 days as moisturizer or lubricant 6 applicators for $19.99
Canesintima Intimate Moisturizer Aqua, glycerin, glyceryl polymethacrylate, capryloyl glycine, sorbitol, acrylates/C10-30 alkyl acrylate crosspolymer, sodium hyaluronate, sodium benzoate, sodium hydroxide, galactoarabinan, butylene glycol/camellia japonica leaf/flower extract, tetrasodium EDTA, P-anisic acid, levulinic acid 5.63 846 Pump bottle 50 mL pump bottle for $33.49
Ah! Yes Vaginal Moisturizer Aqua (water), linum usitatissimum (flax) extract, aloe barbadensis leaf juice powder (aloe vera), ceratonia siliqua (locust bean gum), cyamopsis tetragonolobus (guar gum), sodium chloride, xanthan gum, potassium sorbate, citric acid, phenoxyethanol 3.8 to 4.2 260 to 290 Flip top bottle (100 mL); prefilled applicators used every 3 days $14.99 for flip top bottle, $53.89 for 30 applicators
Sylk Natural Intimate Moisturizer Purified water, kiwifruit plant extract, citrus seed extract, xanthan plant extract, vegetable glycerine, citric acid, potassium sorbate, sodium citrate 4.47 877 3 fluid oz flip top tube $22.95
HyaloGyn Vaginal Hydrating Gel Hydeal-D® (hyaluronic acid derivative), propylene glycol, carbomer (carbopol 974P), methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium hydroxide, purified water 4.88 1336 to 1729 30 g tube with 10 applicators (30-day supply) $27.00
Revaree Vaginal Moisturizer 2-g vaginal insert contains 5 mg of hyaluronic acid sodium salt in a base consisting of a mixture of semi-synthetic glycerides, which help it retain its shape. (Full ingredient list not listed.) Unavailable Unavailable 10 vaginal suppositories (30-day supply) $55.00
K-Y Liquibeads Vaginal Moisturizer Dimethicone, dimethiconol, gelatin, glycerin Unavailable Unavailable 6 vaginal ovules $22.79
References:
  1. Edwards D, Panay N. Treating vulvovaginal atrophy/genitourinary syndrome of menopause: how important is vaginal lubricant and moisturizer composition? Climacteric 2016; 19:151.
  2. Cunha AR, Machado RM, Palmeira de Oliveira A, et al. Characterization of commercially available vaginal lubricants: a safety perspective. Pharmaceuticals 2014; 6:530.

Reproduced with permission from: Pennycuff JF, Iglesia C. How to choose the right vaginal moisturizer or lubricant for your patient. OBG Management 2021; 33:45. Copyright © 2021 Frontline Medical Communications, Inc. https://www.mdedge.com/obgyn (Accessed on August 9, 2022).

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