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Myasthenia gravis composite scale

Myasthenia gravis composite scale
Ptosis, upward gaze (physician examination) >45 seconds = 0 11-45 seconds = 1 1-10 seconds = 2 Immediate = 3
Double vision on lateral gaze, left or right (physician examination) >45 seconds = 0 11-45 seconds = 1 1-10 seconds = 3 Immediate = 4
Eye closure (physician examination) Normal = 0 Mild weakness (can be forced open with effort) = 0 Moderate weakness (can be forced open easily) = 1 Severe weakness (unable to keep eyes closed) = 2
Talking (patient history) Normal = 0 Intermittent slurring or nasal speech = 2 Constant slurring or nasal but can be understood = 4 Difficult to understand speech = 6
Chewing (patient history) Normal = 0 Fatigue with solid food = 2 Fatigue with soft food = 4 Gastric tube = 6
Swallowing (patient history) Normal = 0 Rare episode of choking or trouble swallowing = 2 Frequent trouble swallowing, for example necessitating change in diet = 5 Gastric tube = 6
Breathing (thought to be caused by MG) Normal = 0 Shortness of breath with exertion = 2 Shortness of breath at rest = 4 Ventilator dependence = 9
Neck flexion or extension (weakest) (physician examination) Normal = 0 Mild weakness = 1 Moderate weakness (ie, ~50% weak, ±15%) = 3 Severe weakness = 4
Shoulder abduction (physician examination) Normal = 0 Mild weakness = 2 Moderate weakness (ie, ~50% weak, ±15%) = 4 Severe weakness = 5
Hip flexion (physician examination) Normal = 0 Mild weakness = 2 Moderate weakness (ie, ~50% weak, ±15%) = 4 Severe weakness = 5
TOTAL _________
Please note that "moderate weakness" for neck and limb items should be construed as weakness that equals roughly 50% ± 15% of expected normal strength. Any weakness milder than that would be "mild," and any weakness more severe than that would be classified as "severe."
From: Burns TM, Conaway M, Sanders DB, et al. The MG Composite: A valid and reliable outcome measure for myasthenia gravis. Neurology 2010; 74(18):1434-40. DOI: 10.1212/WNL.0b013e3181dc1b1e. Copyright © 2010 American Academy of Neurology. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
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