Typical histopathological findings

Typical histopathological findings of the normal myocardium (A), lymphocytic myocarditis (B), cellular heart transplant rejection (C), and cardiac amyloidosis (D).

(A) Normal myocardium: No myocyte necrosis, inflammation, or fibrosis.

(B) Acute lymphocytic myocarditis: Many necrotic myocytes (light pink) and numerous CD3+ T cells and other immune cells (eg, CD68+ macrophages).

(D) Cardiac amyloidosis: Congo red staining and subtyping by immunohistochemistry defines cardiac amyloidosis (presented in the figure: transthyretin amyloidosis).

From: Seferović PM, Tsutsui H, McNamara DM, et al. Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy. Eur J Heart Fail 2021; 23:854. https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2190 Copyright © 2021 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).

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Typical histopathological findings