Primary and secondary syphilis – Rates of reported cases by age group and sex, United States, 2021

NOTE: Total includes all ages.

In 2021, the rate of reported primary and secondary syphilis was higher among men (25.2 per 100,000) compared to women (7.3 per 100,000).

Among men, those aged 25 to 29 years had the highest rate of reported cases of primary and secondary syphilis (68.1 per 100,000), followed by men aged 30 to 34 years (67.7 per 100,000) and men aged 35 to 39 years (51.3 per 100,000). Among women, those aged 25 to 29 years also had the highest rate of reported cases of primary and secondary syphilis (22.3 per 100,000), followed by women aged 20 to 24 years (19.5 per 100,000) and women aged 30 to 34 years (18.9 per 100,000).