Syphilis – Rates of reported cases by stage of infection, United States, 2012–2021

In 2021, 176,713 total cases of syphilis, 51,830 cases of early non-primary non-secondary syphilis, and 53,767 cases of primary and secondary syphilis were reported in the United States. During 2020 to 2021, the total rate of syphilis increased 31.7% (40.4 to 53.2 per 100,000), the rate of early non-primary non-secondary syphilis increased 20.0% (13.0 to 15.6 per 100,000), and the rate of primary and secondary syphilis increased 28.6% (12.6 to 16.2 per 100,000).