Substance P in bronchial nerves

Neuronal substance P expression in airway nerves.

(A) Representative image of a three-dimensional z-stack showing substance P expression in a bronchoscopic biopsy from a subject with chronic cough.

(B) Computer-generated mask overlying substance P-positive voxels shown in relation to airway nerve filaments.

Reprinted with permission of the American Thoracic Society. Copyright © 2023 American Thoracic Society. All rights reserved. Shapiro CO, Proskocil BJ, Oppegard LJ, et al. Airway sensory nerve density is increased in chronic cough. Am J Respir Crit Care Med 2021; 203:348. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.

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Substance P in bronchial nerves