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Evaluation and treatment of anemia in pregnancy

Evaluation and treatment of anemia in pregnancy

Iron deficiency is common in pregnancy and is associated with adverse maternal and fetal outcomes, although causation has not been demonstrated. Oral iron takes weeks to months to replete iron stores, depending on the degree of deficiency; this is unlikely to be effective beyond 30 weeks gestation. IV iron repletes stores much more rapidly; some individuals may reasonably choose to use oral iron if they have reasons to avoid IV iron. Transfusion is reserved for severe, symptomatic anemia (Hb <7 g/dL or acute anemia with hemodynamic or respiratory compromise).

Routine prenatal vitamins contain folic acid and may contain iron. The amount of iron in prenatal vitamins is helpful for preventing iron deficiency but is not sufficient for treating iron deficiency.

CBC: complete blood count; IV: intravenous; Hb: hemoglobin.

* Ferritin <30 ng/mL (<30 mcg/L) confirms iron deficiency. Ferritin ≥30 ng/mL is sufficient to rule out iron deficiency in the absence of chronic illness. Refer to UpToDate for additional information on diagnosing iron deficiency and evaluating other causes of anemia in pregnancy.
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