ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Recommended wait time for SOT candidates with a prior history of colon cancer

Recommended wait time for SOT candidates with a prior history of colon cancer
Risk/stage Recurrence-free survival 5 years (%) Time interval to transplant Additional considerations
Low risk
  • Stage I (T1 or T2, N0, M0)
 91 1 year Low-risk features:
  • Deficient DNA mismatch repair (as reflected by high levels of MSI) without BRAF mutation

High-risk features:

  • LVI or PNI
  • Mucinous or signet histology
  • Poorly differentiated histology
  • Bowel obstruction
  • Tumor perforation
  • <12 lymph nodes examined

Tumor deposits considered as N+ disease.

Consider chemotherapy prior to transplantation for high-risk stage II disease.

Patients with stage III disease should complete chemotherapy.
Low intermediate risk
  • Stage II (T3, N0, M0)
 72 2 years, consider longer if high-risk features present
High intermediate risk
  • Stage II (T4, N0, M0)
  • Stage III (Any T, N+, M0)
   3 years, 5 years if high-risk features present
High risk
  • Stage IV (Any T, Any N, M+)
 13 5 years NED SOT not recommended prior to 5 years; refer to special consideration regarding resectable CRC metastasis
LVI: lymphovascular invasion; PVI: perineural invasion; MSI: microsatellite instability; CT: computed tomography; CAP: chest, abdomen and pelvis; CEA: carcinoembryonic antigen; NED: no evidence of disease.
From: Al-Adra DP, Hammel L, Roberts, J, et al. Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement. Am J Transplant 2021; 21:460. https://onlinelibrary.wiley.com/doi/10.1111/ajt.16318. Copyright © 2021 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).
Graphic 135214 Version 2.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟