Criteria for safe SOT candidates with a prior history of myeloma (top) or amyloidosis (bottom)

Criteria for safe renal transplantation in myeloma

Stringent complete response

No monoclonal protein in serum or urine by immunofixation

Normal free light chain ratio

Bone marrow plasma cells <1% by flow or immunohistochemistry

Performance status 0 or 1

FISH at diagnosis fail to demonstrate deletion (17p), t(4;14), t(14;16)

Hematologic remission >6 months

Criteria for organ transplantation in amyloidosis

Therapeutic response with dFLC of <4 mg/dl

Only one organ involved with amyloidosis

Does not fulfill criteria for symptomatic myeloma

Must be a candidate for stem cell transplantation following organ transplantation

dFLC: difference between involved minus uninvolved serum free light chains.

From: Al-Adra DP, Hammel L, Roberts J, et al. Preexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: A consensus expert opinion statement. Am J Transplant 2021; 21:475. https://onlinelibrary.wiley.com/doi/10.1111/ajt.16324. Copyright © 2021 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).

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Criteria for safe SOT candidates with a prior history of myeloma (top) or amyloidosis (bottom)