Change in ferritin levels over time in 83 children who participated in the SIT trial and were assigned to receive transfusions for 1 year. In the patients receiving automated red cell exchange (red squares), ferritin values did not increase above 500 ng/mL. In contrast, those who received manual exchange or simple transfusion had progressive increases in serum ferritin.
From: Kelly S, Rodeghier M, DeBaun MR. Automated exchange compared to manual and simple blood transfusion attenuates rise in ferritin level after 1 year of regular blood transfusion therapy in chronically transfused children with sickle cell disease. Transfusion 2020; 60:2508.
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