Schematic diagrams showing (A) car stationed away from wall, representing mesencephalon (car) and occipital bone (wall) in normal fetuses, and (B) reversed into wall, representing posterior displacement of mesencephalon and deformation against occipital bone ("crash sign") in fetuses with open spina bifida. Ultrasound images in axial view at 12 to 13 weeks of gestation, showing mesencephalon in normal fetuses (C,E,G) and crash sign in fetuses with open spina bifida (D,F,H). Three-dimensional reconstructed images of two sets of monochorionic twins discordant for spina bifida: Images of singleton fetuses without (G) and with (H) crash sign (arrow).
From: Ushakov F, Sacco A, Andreeva E, et al. Crash sign: new first-trimester sonographic marker of spina bifida. Ultrasound Obstet Gynecol 2019; 54:740.
https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.20285. Copyright © 2019 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email:
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