Medications that may interfere with sleep architecture

An American Academy of Sleep Medicine task force recommends that the agents listed in the table (medications that can affect rapid eye movement [REM] sleep and/or nonrapid eye movement sleep latency) be tapered before the multiple sleep latency test (MSLT) to minimize medication and substance effects.
A 2-week washout is generally recommended; agents with an asterisk have long half-lives, and longer washout (up to 6 weeks) may be needed. The table includes commonly encountered medications or those requiring a prolonged washout period, but it is not an exhaustive list.