Revised International Staging System for multiple myeloma

Stage I	Stage II	Stage III
All of the following: B2M <3.5 mg/L Serum albumin ≥3.5 g/dL Normal LDH No del(17p), t(4;14), or t(14;16) by FISH	Neither stage I nor stage III	Both of the following: B2M ≥5.5 mg/L Elevated LDH and/or del(17p), t(4;14), or t(14;16) by FISH

B2M: beta-2 microglobulin; LDH: lactate dehydrogenase; FISH: fluorescence in situ hybridization.

Adapted from: Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J Clin Oncol 2015; 33:2863.

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