Trans-ancestry GWAS meta-analysis identifies 318 loci associated with type 2 diabetes

The figure displays results from a trans-ancestry GWAS meta-analysis of 228,499 type 2 diabetes cases and 1,178,783 controls. The outer track shows a Manhattan plot bent into a circle with SNPs ordered by chromosomal position and their Pvalues for association with type 2 diabetes displayed as –log₁₀(Pvalue). The red line indicates a threshold of genome-wide significant (Pvalue = 5×10^–8). The top SNPs were analyzed for association with gene expression in various tissues (eQTL), and the genes for which eQTLs were found are displayed along the outer edge with the color indicating the tissue: purple for skeletal muscle, red for adipose, black for pancreas, and blue for arteries. The green band below the Manhattan plot corresponds to measures of heterogeneity for index SNPs across studies with larger dots indicating greater heterogeneity. The inner track displays the associations of the eQTLs for each SNP in the same tissues as noted above, displayed as –log₁₀(Pvalue), with the red line indicating genome-wide significance. The inset contains the 318 novel loci identified in this study stratified by ancestral group and then plotted by their minor allele frequency (MAF) and the absolute value of the effect size (beta) for their association with type 2 diabetes.