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CPS + EG score calculation

CPS + EG score calculation
Stage or feature Points
Clinical stage (AJCC staging[1])
I 0
IIA 0
IIB 1
IIIA 1
IIIB 2
IIIC 2
Pathologic stage (AJCC staging[1])
0 0
I 0
IIA 1
IIB 1
IIIA 1
IIIB 1
IIIC 2
Receptor status
ER-negative 1
Nuclear grade*
Nuclear grade 3 1
CPS + EG score calculation instructions: Add the points for clinical stage + pathologic stage + ER status + nuclear grade to derive a sum between 0 and 6.
CPS + EG: clinical stage + pathologic stage + ER status + nuclear grade; ER: estrogen receptor; AJCC: American Joint Committee on Cancer.
* In the unlikely situation nuclear grade cannot be determined, regular histologic grade should be used; if only Nottingham overall grade is reported, the Nottingham overall grade must be 9 to be scored as 1 point in the CPS + EG score.
From: Tutt AN, Garber JE, Kaufman B, et al. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. N Engl J Med 2021; 384:2394. Copyright © 2021 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
Reference:
  1. AJCC (American Joint Committee on Cancer): Cancer Staging Manual, 8th ed, Springer, 2017.
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