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Dobutamine: Pediatric drug information

Dobutamine: Pediatric drug information
2024© UpToDate, Inc. and its affiliates and/or licensors. All Rights Reserved.
For additional information see "Dobutamine: Drug information" and "Dobutamine: Patient drug information"

For abbreviations, symbols, and age group definitions show table
Therapeutic Category
  • Adrenergic Agonist Agent;
  • Sympathomimetic
Dosing: Neonatal
Hemodynamic support

Hemodynamic support: Preterm and Term Neonates: Continuous IV or intraosseous infusion: Initial: 0.5 to 1 mcg/kg/minute; titrate gradually every few minutes until desired response achieved; usual range: 2 to 20 mcg/kg/minute (Ref).

Dosing: Pediatric
Hemodynamic support

Hemodynamic support: Infants, Children, and Adolescents: Continuous IV or intraosseous infusion: Initial: 0.5 to 1 mcg/kg/minute; titrate gradually every few minutes until desired response achieved; usual range: 2 to 20 mcg/kg/minute (Ref).

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Adult

(For additional information see "Dobutamine: Drug information")

Acute decompensated heart failure

Acute decompensated heart failure: Note: May consider for short-term use in patients with low cardiac index and hypotension or end-organ hypoperfusion (Ref).

Continuous infusion: IV: Initial: 2 to 5 mcg/kg/minute; titrate based on clinical end point (eg, systemic perfusion or end-organ perfusion); usual dosage range: 2 to 10 mcg/kg/minute; maximum dose: 20 mcg/kg/minute (Ref).

Inotropic support

Inotropic support (off-label use): Note: In patients with shock (eg, sepsis) who fail to meet hemodynamic goals with vasopressor therapy (eg, norepinephrine), dobutamine may be added to vasopressor therapy if there is continued hypoperfusion despite volume resuscitation (Ref).

Continuous infusion: IV: Initial: 2 to 5 mcg/kg/minute; titrate based on clinical end point (eg, BP, end-organ perfusion); usual dosage range: 2 to 10 mcg/kg/minute; however, doses as low as 0.5 mcg/kg/min have been used in less severe cardiac decompensation; maximum dose: 20 mcg/kg/minute (Ref).

Stress echocardiography, routine

Stress echocardiography, routine (diagnostic agent) (off-label use): Continuous infusion: IV: Initial: 5 mcg/kg/minute; increase at 3-minute intervals to 10 mcg/kg/minute, then 20 mcg/kg/minute, then 30 mcg/kg/minute, and then 40 mcg/kg/minute. May coadminister atropine in patients who do not achieve target heart rate (Ref).

Stress echocardiography, viability assessment

Stress echocardiography, viability assessment (diagnostic agent) (off-label use): Continuous infusion: IV: Initial: 2.5 mcg/kg/minute; increase at 5-minute intervals in 2.5 mcg/kg/minute increments until contractile response is noted, up to a maximum dose of 10 mcg/kg/minute (Ref).

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Note: In patients with CrCl <20 mL/minute receiving dobutamine continuous infusion for treatment of acute decompensated heart failure, dobutamine-induced myoclonus has been reported as a rare, but perhaps underrecognized, adverse effect (Ref).

Altered kidney function: No dosage adjustment necessary for any degree of kidney dysfunction (excreted in the urine as inactive metabolites) (Ref).

Hemodialysis, intermittent (thrice weekly): Dialysis removal unknown (some expected based on small volume of distribution); no supplemental dose or dosage adjustment necessary (Ref).

Peritoneal dialysis: Dialysis removal unknown (some expected based on small volume of distribution); no dosage adjustment necessary (Ref).

CRRT: No dosage adjustment likely to be necessary (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration): No dosage adjustment likely to be necessary (Ref).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

1% to 10%:

Cardiovascular: Angina pectoris (1% to 3%), chest pain (1% to 3%), increased heart rate (10%), increased systolic blood pressure (8%), palpitations (1% to 3%), premature ventricular contractions (5%)

Gastrointestinal: Nausea (1% to 3%)

Nervous system: Headache (1% to 3%)

Respiratory: Dyspnea (1% to 3%)

Frequency not defined:

Cardiovascular: Decreased blood pressure, ventricular tachycardia

Endocrine & metabolic: Decreased serum potassium

Local: Localized phlebitis

Postmarketing:

Cardiovascular: Atrial fibrillation (Wirtz 1995), bradycardia (Olszowska 2012), cardiomyopathy (Chandraprakasam 2015), coronary artery vasospasm (Yamagishi 1998), heart block (Vaidyanathan 2008), left ventricular dysfunction (takotsubo syndrome) (Mangolini 2020), torsade de pointes (Quan 2009)

Hematologic & oncologic: Eosinophilia (Maaliki 2021)

Hypersensitivity: Hypersensitivity reaction

Nervous system: Chills (Poldermans 1993), myoclonus (Noel 2022), shivering (Poldermans 1993)

Contraindications

Hypersensitivity to dobutamine or sulfites (some contain sodium metabisulfate), or any component of the formulation; hypertrophic cardiomyopathy with outflow tract obstruction (formerly known as idiopathic hypertrophic subaortic stenosis).

Canadian labeling: Additional contraindications (not in the US labeling): Pheochromocytoma.

Note: When utilized for stress testing, additional contraindications according to the American Society of Nuclear Cardiology include patients with recent (<2 to 4 days) myocardial infarction, unstable angina, severe aortic stenosis, atrial tachyarrhythmias with uncontrolled ventricular response, prior history of ventricular tachycardia, uncontrolled hypertension (>200/110 mm Hg), and aortic dissection or large aortic aneurysm (ASNC [Henzlova 2016]).

Warnings/Precautions

Concerns related to adverse effects:

• Arrhythmias: Ventricular arrhythmias, including nonsustained ventricular tachycardia and supraventricular arrhythmias, have been reported (Tisdale 1995). Observe closely for arrhythmias in patients with decompensated heart failure; sudden cardiac death has been observed (O’Connor 1999; Pickworth 1992; Young 2000). Ensure that ventricular rate is controlled in atrial fibrillation/flutter before initiating; may increase ventricular response rate.

• BP effects: An increase in BP is more common due to augmented cardiac output, but hypotension secondarily to vasodilation may occur at higher doses.

• Heart failure complications: An increased risk of hospitalization and death has been observed with prolonged use in New York Heart Association Class III/IV heart failure patients (O’Connor 1999).

• Tachycardia: May cause dose-related increases in heart rate.

• Ventricular ectopy: May exacerbate ventricular ectopy (dose related).

Disease-related concerns:

• Aortic stenosis: Ineffective therapeutically in the presence of mechanical obstruction such as severe aortic stenosis.

• Electrolyte imbalance: Correct electrolyte disturbances, especially hypokalemia or hypomagnesemia, prior to use and throughout therapy to minimize the risk of arrhythmias (ACC/AHA/ESC [Zipes 2006]; Tisdale 1995).

• Hypovolemia: If needed, correct hypovolemia first to optimize hemodynamics.

• Active myocardial ischemia/myocardial infarction (post): Use with caution in patients with active myocardial ischemia or recent myocardial infarction; can increase myocardial oxygen demand.

Concurrent drug therapy issues:

• Monoamine oxidase inhibitors: Use with extreme caution in patients taking monoamine oxidase inhibitors; prolong hypertension may result from concurrent use.

Dosage form specific issues:

• Sodium sulfite: Product may contain sodium sulfite.

Special populations:

• Older adults: Use with caution in older adults; start at lower end of the dosage range.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Intravenous, as hydrochloride:

Generic: 1 mg/mL (250 mL); 4 mg/mL (250 mL); 250 mg/20 mL (20 mL); 1 mg/mL (250 mL); 2 mg/mL (250 mL); 4 mg/mL (250 mL)

Solution, Intravenous, as hydrochloride [preservative free]:

Generic: 12.5 mg/mL (20 mL)

Generic Equivalent Available: US

Yes

Pricing: US

Solution (DOBUTamine HCl Intravenous)

12.5 mg/mL (per mL): $0.39 - $0.46

Solution (DOBUTamine-Dextrose Intravenous)

1 mg/mL 5% (per mL): $0.04 - $0.11

2 mg/mL 5% (per mL): $0.07 - $0.19

4 mg/mL 5% (per mL): $0.09 - $0.14

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Intravenous, as hydrochloride:

Generic: 12.5 mg/mL (20 mL)

Additional Information

Dobutamine lowers central venous pressure and wedge pressure but has little effect on pulmonary vascular resistance.

Administration: Pediatric

Parenteral: Continuous IV infusion: Vials (concentrated solution) must be diluted prior to administration; premixed IV solutions (1,000 mcg/mL, 2,000 mcg/mL, 4,000 mcg/mL) are available. Administer as a continuous IV infusion via an infusion device. Central line administration is preferred; if central line not available, may administer for a short duration through a peripheral IV catheter placed in a large vein or via intraosseous access (Ref). Administration into an umbilical arterial catheter is not recommended (Ref). Frequent monitoring of the IV catheter site is recommended to rapidly identify extravasation (Ref). Refer to institutional policies and procedures; catheter placement/size and vasopressor concentration may vary depending on institution.

Rate of infusion (mL/hour) = dose (mcg/kg/minute) × weight (kg) × 60 minutes/hour divided by the concentration (mcg/mL)

May be a vesicant; avoid extravasation. If extravasation occurs, stop infusion immediately; leave cannula/needle in place temporarily but do NOT flush the line; gently aspirate extravasated solution, then remove needle/cannula; elevate extremity; apply dry, warm compresses. Initiate phentolamine (or alternative antidote) in severe cases (Ref).

Administration: Adult

IV: Always administer via infusion device; administer into large vein.

May be a vesicant; avoid extravasation.

Extravasation management: If extravasation occurs, stop infusion immediately; leave cannula/needle in place temporarily but do NOT flush the line; gently aspirate extravasated solution, then remove needle/cannula; elevate extremity; apply dry, warm compresses; initiate phentolamine antidote in severe cases (eg, when local tissue concentration is high) in addition to supportive management (Ref).

Phentolamine: SUBQ: Dilute 5 to 10 mg in 10 mL NS and administer into extravasation site as soon as possible after extravasation; if IV catheter remains in place, administer initial dose intravenously through the infiltrated catheter; may repeat in 60 minutes if patient remains symptomatic (Ref).

Alternatives to phentolamine:

Nitroglycerin topical 2% ointment: Apply a 1-inch strip to the site of ischemia to cover affected area; may repeat every 8 hours as necessary (Ref).

Terbutaline: SUBQ: Infiltrate extravasation area with terbutaline 1 mg using a solution of terbutaline 1 mg diluted in 10 mL NS. May repeat dose after 15 minutes (Ref).

Usual Infusion Concentrations: Neonatal

Note: Premixed solutions available.

IV infusion: 1,000 mcg/mL, 2,000 mcg/mL, or 4,000 mcg/mL

Usual Infusion Concentrations: Pediatric

Note: Premixed solutions available.

IV infusion: 1,000 mcg/mL, 2,000 mcg/mL, or 4,000 mcg/mL

Storage/Stability

Premixed solution: Store at 20°C to 25°C (68°F to 77°F). Pink discoloration of solution indicates slight oxidation, but no significant loss of potency.

Vials: Store intact vials at 20°C to 25°C (68°F to 77°F). Following dilution in a compatible solution, use within 24 hours.

Use

Short-term management of cardiac decompensation due to decreased contractility (provides inotropic support) (FDA approved in all ages). Note: Approved ages vary by product; consult product-specific labeling for details.

Medication Safety Issues
Sound-alike/look-alike issues:

DOBUTamine may be confused with DOPamine

High alert medication:

The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drug classes (inotropic medications, IV) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Acute Care Settings).

Metabolism/Transport Effects

Substrate of COMT

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program

Atomoxetine: May enhance the hypertensive effect of Sympathomimetics. Atomoxetine may enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

Beta-Blockers: May diminish the therapeutic effect of DOBUTamine. Risk C: Monitor therapy

Calcium Salts: May diminish the therapeutic effect of DOBUTamine. Risk C: Monitor therapy

Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Risk D: Consider therapy modification

COMT Inhibitors: May increase the serum concentration of COMT Substrates. Risk C: Monitor therapy

Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Risk C: Monitor therapy

Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Risk C: Monitor therapy

Kratom: May enhance the adverse/toxic effect of Sympathomimetics. Risk X: Avoid combination

Levothyroxine: May enhance the adverse/toxic effect of Sympathomimetics. Specifically, the risk of coronary insufficiency may be increased in patients with coronary artery disease. Levothyroxine may enhance the therapeutic effect of Sympathomimetics. Sympathomimetics may enhance the therapeutic effect of Levothyroxine. Risk C: Monitor therapy

Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Consider initial dose reductions of sympathomimetic agents, and closely monitor for enhanced blood pressure elevations, in patients receiving linezolid. Risk D: Consider therapy modification

Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Risk C: Monitor therapy

Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Risk C: Monitor therapy

Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Risk C: Monitor therapy

Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

Pregnancy Considerations

Dobutamine should not be used as a diagnostic agent for stress testing during pregnancy; use should be avoided when other options are available (ESC [Regitz-Zagrosek 2018]). Medications used for the treatment of cardiac arrest in pregnancy are the same as in the non-pregnant female. Appropriate medications should not be withheld due to concerns of fetal teratogenicity. Dobutamine use during the post-resuscitation phase may be considered; however, the effects of inotropic support on the fetus should also be considered. Doses and indications should follow current Advanced Cardiovascular Life Support (ACLS) guidelines (AHA [Jeejeebhoy 2015 ]).

Monitoring Parameters

Blood pressure, ECG, heart rate, central venous pressure, mean arterial pressure, urine output; if pulmonary artery catheter is in place, monitor cardiac index, pulmonary capillary wedge pressure, right atrial pressure, and systemic vascular resistance.

Mechanism of Action

Dobutamine, a racemic mixture, stimulates myocardial beta1-adrenergic receptors primarily by the (+) enantiomer and some alpha1 receptor agonism by the (-) enantiomer, resulting in increased contractility and heart rate, and stimulates both beta2- and alpha1-receptors in the vasculature. Although beta2 and alpha1 adrenergic receptors are also activated, the effects of beta2 receptor activation may equally offset or be slightly greater than the effects of alpha1 stimulation, resulting in some vasodilation in addition to the inotropic and chronotropic actions (Leier 1988; Majerus 1989; Ruffolo 1987). Lowers central venous pressure and wedge pressure, but has little effect on pulmonary vascular resistance (Leier 1977; Leier 1978).

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: IV: 1 to 10 minutes

Peak effect: 10 to 20 minutes

Metabolism: In tissues and hepatically (via conjugation and methylation) to inactive metabolites.

Half-life elimination: 2 minutes

Excretion: Urine (as inactive metabolites).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Dobutamine hameln | Dobutrex;
  • (AR) Argentina: Dobucard | Dobutamina | Dobutamina bioquim | Dobutamina drawer | Dobutamina fabra | Dobutamina gray | Dobutamina Norgreen | Dobutrex | E.m.c. dobutamina;
  • (AT) Austria: Dobutamin | Dobutamin hameln | Inotop;
  • (AU) Australia: Dobutamine | Dobutamine bc | Dobutamine claris | Dobutamine hameln | Dobutamine HCL | Dobutrex;
  • (BD) Bangladesh: Dobumin | Dobutamine abbott | Dobutin;
  • (BE) Belgium: Dobutamine Baxter | Dobutamine eg | Dobutamine mayne pharma (ben) | Dobutrex;
  • (BG) Bulgaria: Dobutamin | Dobutamin hameln | Dobutrex;
  • (BR) Brazil: Cloridrato de dobutamina | Dobtan | Dobu | Dobutal | Dobutamol | Dobutanil | Dobutariston | Dobutrex | Hibutan;
  • (CH) Switzerland: Dobutamin | Dobutamin fresenius | Dobutrex;
  • (CN) China: Dobutamine | Dobutrex | Feng hai fen;
  • (CO) Colombia: Autobod | Dobutamina | Dobutrex | Docarip | Dotropina | Duvig;
  • (CZ) Czech Republic: Dobuject | Dobutamin | Dobutamin admeda | Dobutamin hameln;
  • (DE) Germany: Dobutamin | Dobutamin carinopharm | Dobutamin hameln | Dobutamin hexal;
  • (DO) Dominican Republic: Dobutrex | Dotropina | Inoject;
  • (EC) Ecuador: Dobutam | Dobutamina | Dobutamina sanderson;
  • (EE) Estonia: Dobcard | Dobuject | Dobutamine claris | Dobutamine hameln | Dobutamine HCL | Dobutamine merck | Dobutamine mylan | Dobuthaver | Dobutrex | Mekard;
  • (EG) Egypt: Dobutamine | Dobutrex | Dubuject;
  • (ES) Spain: Dobucor | Dobutamina abbott | Dobutamina inibsa | Dobutamina rovi | Dobutrex;
  • (FI) Finland: Dobuject | Dobutamin abbott | Dobutrex;
  • (FR) France: Dobutamine | Dobutamine Aguettant | Dobutamine Baxter | Dobutamine dakota | Dobutamine merck | Dobutamine Panpharma | Dobutamine Qualimed | Dobutamine winthrop | Dobutrex;
  • (GB) United Kingdom: Dobutamine | Dobutrex | Posiject;
  • (GR) Greece: Dobutamine HCL | Dobutan;
  • (HK) Hong Kong: Dobutamine;
  • (HU) Hungary: Dobuject | Dobutamin admeda | Dobutamin hameln | Dobutamina panpharma | Dobutrex;
  • (ID) Indonesia: Cardiject | Dobuca | Dobuject | Doburan | Dobutamin | Dobutamine | Dobutel | Dobutrex | Domine | Dominic | Inodex | Inotrop;
  • (IE) Ireland: Dobutamine | Posiject;
  • (IN) India: Cardiforce | Dobicard | Dobier s | Dobunex pf | Dobusol | Dobustat | Inoject;
  • (IT) Italy: Dobutamina abbott | Dobutamina bioindustria | Dobutamina Hikma | Dobutrex | Miozac;
  • (JP) Japan: Bubucin | Doburack | Dobutamine | Dobutrex | Dobux | Dobux nichiiko | Dopmin | Doputamin | Doputamin Fuji | Doputamin h hexal | Hercarenone d | Retamex;
  • (KR) Korea, Republic of: Aukomine | Dobamine | Dobuject | Doburan | Dobutamine | Dobutamine hcl and dextrose | Dobutamine hcl injection huons | Dobutrex | Myungmoon Dobutamine HCL | Toburex;
  • (KW) Kuwait: Dobuject | Dobutrex;
  • (LB) Lebanon: Dobutamin | Dobutrex;
  • (LT) Lithuania: Dobuject | Dobutamin | Dobutamina panpharma | Dobutamine claris | Dobutamine hameln | Dobutrex;
  • (LV) Latvia: Dobuject | Dobutamin | Dobutamine claris | Dobutamine mylan | Dobutrex;
  • (MA) Morocco: Dobutrex;
  • (MX) Mexico: Adregotec | Corbusin | Cryobutol | Dobuject | Dobutamina | Dobutamina gi tecn;
  • (MY) Malaysia: Dobutamine | Mobitil;
  • (NL) Netherlands: Dobutamine | Dobutamine CF | Dobutamine claris;
  • (NO) Norway: Dobutamin | Dobutrex;
  • (NZ) New Zealand: Dobutamine | Dobutamine claris | Dobutamine hameln;
  • (PE) Peru: Dobutamina | Dobutrex;
  • (PH) Philippines: Abbott dobutamine hydrochloride | Cardease | Cardiotrex | Cardob | Dobine | Dobucard | Dobucore | Dobuject | Dobulex | Dobumarc | Dobumean | Doburan | Dobutamine | Dobutamine Baxter | Dobutrex | Dobutrim | Dobuzef | Inocard | Pusogard;
  • (PK) Pakistan: Dobamin | Dobutine | Dobutrex;
  • (PL) Poland: Dobuject | Dobutrex;
  • (PR) Puerto Rico: Dobutamine | Dobutamine HCL | Dobutrex;
  • (PT) Portugal: Dasomin | Dobucor | Dobutamina | Dobutamina Aps | Dobutamina Claris | Dobutamina Generis | Dobutamina genthon | Dobutamina Hikma | Dobutina | Inotrex;
  • (PY) Paraguay: Dobuject | Dobutamina sanderson | E.m.c.;
  • (QA) Qatar: Dobcard | Dobuject | Dobutasel | Dobuthaver;
  • (RO) Romania: Dobutamin admeda | Dobutamina | Dobutamina panpharma;
  • (RU) Russian Federation: Dobutamin admeda | Dobutamine | Dobutel | Dobutrex;
  • (SA) Saudi Arabia: Dobuject | Dobutamin | Dobutamine;
  • (SE) Sweden: Dobutamin hameln | Dobutrex;
  • (SG) Singapore: Dobutamine | Dobutrex;
  • (SI) Slovenia: Dobutamin | Dobutamin hameln | Inotop;
  • (SK) Slovakia: Dobutamin | Dobutrex;
  • (TH) Thailand: Cardiject | Dobucin | Dobutamine | Dobutamine abbott | Dobutamine hcl DBL | Dobutel | Dobutrex;
  • (TN) Tunisia: Dobutamine mylan | Dobutamine Panpharma;
  • (TR) Turkey: Dobcard | Dobutamin | Dobutasel | Dobuthaver | Mekard;
  • (TW) Taiwan: Butamine | Dobuha | Dobuject | Dobutamine | Dobutamine HCL | Dobutrex | Easydobu | Gendobu | Utamine;
  • (UA) Ukraine: Cardiject | Clebutam | Dobutamin admeda | Dobutamin ebewe | Dobutel;
  • (UY) Uruguay: Dobutam | Dobutamina | Dobutamina blaufarma | Dobutamina fu | Duvig;
  • (VE) Venezuela, Bolivarian Republic of: Doburan | Dobutamina | Dobutrex | Dobuxin;
  • (ZA) South Africa: Dobutamine
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