Screening test | Components | Gestational age at testing (weeks) | Detection/screen positive rates for trisomy 21 | Comments |
First trimester combined | NT+PAPP-A, free beta-hCG or NT+PAPP-A, intact/total hCG | Blood at 11+0 to 13+6
NT at 10+3 to 13+6 | 85% / 5% |
|
Quadruple | hCG, AFP, uE3, DIA | Blood at 15+0 to 18+6 (can be through 22+6) | 80% / 5% |
|
Integrated or sequential | PAPP-A+NT and hCG, AFP, uE3, DIA | First blood draw and NT are at the same time as for combined test Second blood draw is at the same time as for quadruple test | 94% / 5% or 85% / 2% |
|
Serum integrated | Same as integrated but without NT | First blood draw at the same time as for combined test Second blood draw is at the same time as for quadruple test | 85% / 5% | Best test for those without access to NT scans or early diagnosis by CVS |
Cell-free DNA | Genome-wide or targeted methods | Blood at 10+0 or later | 99.2% / 0.08% |
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