Histopathologic features of BAP1-inactivated melanocytoma

Cutaneous BIM.

(A) This tumor has an overall polypoidal configuration with a biphasic pattern (H&E ×20).

(B) Positive nuclear BAP1 staining in small, peripheral melanocytes and epidermal keratinocytes (×100).

(C) Biphasic proliferation of melanocytes with large epithelioid cells (left) and smaller melanocytes with less cytoplasm (right) (H&E ×400).

(D) Absent BAP1 nuclear staining in large melanocytes (left) and retained nuclear BAP1 expression in small melanocytes (right) (×400).

(E, F, and G) Examples of variable cytologic atypia (H&E ×400, ×630, and ×400, respectively).

(H) BRAF V600E staining in both the small nevic population (top) and large epithelioid BAP1-deficient population (bottom) (×200).

BIM: BAP1-inactivated melanocytoma; H&E: hematoxylin and eosin.

From: Zhang AJ, Rush PS, Tsao H, Duncan LM. BRCA1-associated protein (BAP1)-inactivated melanocytic tumors. J Cutan Pathol 2019; 46:965. https://onlinelibrary.wiley.com/doi/10.1111/cup.13530. Copyright © 2019 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).

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Histopathologic features of BAP1-inactivated melanocytoma