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Segmental distribution of divalent cation transport

Segmental distribution of divalent cation transport
Schematic diagram of cells of the distal nephron, including thick ascending limb (TAL) cells, distal convoluted tubule (DCT) cells, and distal convoluted tubule 2/connecting tubule cells (DCT2/CNT). Calcium (Ca2+) and magnesium (Mg2+) traverse a paracellular pathway along the TAL composed of the claudins 16 and 19. Mg2+ is reabsorbed along the DCT via an apical channel, TRPM6. Ca2+, by contrast, is reabsorbed along the DCT2/CNT by a different apical channel, TRPV5. Disruption of transport processes along one segment leads to compensation of transport along others.
Courtesy of David H Ellison, MD, FASN, FAHA.
Graphic 131046 Version 2.0

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