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Vitamin D3 (cholecalciferol): Pediatric drug information

Vitamin D3 (cholecalciferol): Pediatric drug information
(For additional information see "Vitamin D3 (cholecalciferol): Drug information" and see "Vitamin D3 (cholecalciferol): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Aqueous Vitamin D [OTC];
  • BProtected Pedia D-Vite [OTC];
  • D-3-5 [OTC];
  • D-Vi-Sol [OTC];
  • D-Vite Pediatric [OTC];
  • D3-50 [OTC];
  • Decara [OTC];
  • Delta D3 [OTC];
  • Dialyvite 5000;
  • Dialyvite Vitamin D 5000 [OTC];
  • Dialyvite Vitamin D3 Max [OTC];
  • Osteo-Vit3 [OTC];
  • Pronutrients Vitamin D3 [OTC];
  • True Vitamin D3 [OTC];
  • VitaChew Vitamin D3 [OTC];
  • Vitamin D3 Ultra Potency [OTC];
  • Vitamin D3 [OTC];
  • Weekly-D [OTC]
Brand Names: Canada
  • AG-Vitamin D;
  • D-Tabs;
  • EURO D 10000;
  • EURO-D;
  • JAMP-Vitamin D;
  • Luxa-D;
  • SANDOZ D 10000;
  • ViDextra
Therapeutic Category
  • Nutritional Supplement;
  • Vitamin D Analog;
  • Vitamin, Fat Soluble
Dosing: Neonatal

Note: 1 mcg = 40 units.

Adequate intake (AI): Oral: 400 units/day (10 mcg/day) (IOM 2011).

Vitamin D deficiency, prevention

Vitamin D deficiency, prevention:

Preterm neonates:

Birthweight ≤1.5 kg: Oral: Initial: 200 units (5 mcg) daily; increase to 400 units (10 mcg) daily when weight >1.5 to 2 kg and tolerating full enteral nutrition (AAP [Abrams 2013]); some experts recommended higher doses of 800 to 1,000 units (20 to 25 mcg) daily for stable growing preterm neonates weighing 1 to 1.8 kg (ESPGHAN [Agostoni 2010]).

Birthweight >1.5 kg: Oral: 400 units (10 mcg) daily when tolerating full enteral nutrition (AAP [Abrams 2013]); some experts recommended higher doses of 800 to 1,000 units (20 to 25 mcg) daily for stable growing preterm neonates up to 1.8 kg (ESPGHAN [Agostoni 2010]).

Full-term neonates: Breastfed (fully or partially): Oral: 400 units (10 mcg) daily beginning in the first few days of life; continue supplementation unless infant is transitioned to full formula intake (AAP [Golden 2014]; Abrams 2020).

Vitamin D deficiency, treatment

Vitamin D deficiency (severe, symptomatic), treatment: Full-term neonates: Oral: 2,000 units (50 mcg) daily for 6 weeks to achieve a serum 25(OH)D level >20 ng/mL; followed by a maintenance dose of 400 to 1,000 units (10 to 25 mcg) daily. Monitor vitamin D status closely; treatment should also include calcium supplementation (AAP [Golden 2014]; Munns 2016). A lower dose of 1,000 units (25 mcg) daily has also been recommended (AAP [Misra 2008]).

Dosing: Pediatric

Note: 1 mcg = 40 units.

Vitamin D deficiency, prevention

Vitamin D deficiency, prevention (eg, Rickets prevention): (AAP [Golden 2014]; Abrams 2020; Munns 2016):

Breastfed infants (fully or partially): Oral: 400 units (10 mcg) daily beginning in the first few days of life; continue supplementation unless infant is transitioned to full formula intake.

Children and Adolescents without adequate intake: Oral: 600 units (15 mcg) daily. Note: Children with increased risk of vitamin D deficiency (chronic fat malabsorption, maintained on chronic antiseizure medications) may require higher doses; use laboratory testing [25(OH)D, PTH, bone mineral status] to evaluate.

Vitamin D deficiency, treatment

Vitamin D deficiency (severe, symptomatic), treatment: Note: Treatment should also include calcium supplementation; some patients with chronic fat malabsorption, obesity, or who are maintained on chronic antiseizure medications, glucocorticoids, HIV medications, or antifungals may require higher doses of cholecalciferol (AAP [Golden 2014]); monitor vitamin D status closely.

Infants: Oral: 2,000 units (50 mcg) daily for 6 weeks to achieve a serum 25(OH)D level >20 ng/mL; followed by a maintenance dose of 400 to 1,000 units (10 to 25 mcg) daily. Note: For patients at high risk of fractures a serum 25(OH)D level >30 ng/mL has been suggested (AAP [Golden 2014]).

Children and Adolescents: Oral: 2,000 units (50 mcg) daily for 6 to 8 weeks to achieve serum 25(OH)D level >20 ng/mL; followed by a maintenance dose of 600 to 1,000 units (15 to 25 mcg) daily. Note: For patients at high risk of fractures a serum 25(OH)D level >30 ng/mL has been suggested (AAP [Golden 2014]).

Vitamin D deficiency in cystic fibrosis, prevention and treatment

Vitamin D deficiency in cystic fibrosis, prevention and treatment:

CF guidelines (CF Foundation [Tangpricha 2012]):

Recommended initial daily intake to maintain serum 25(OH)D level ≥30 ng/mL:

Infants: Oral: 400 to 500 units (10 to 12.5 mcg) once daily.

Children ≤10 years: Oral: 800 to 1,000 units (20 to 25 mcg) once daily.

Children >10 years and Adolescents: Oral: 800 to 2,000 units (20 to 50 mcg) once daily.

Dosing adjustment for serum 25(OH)D level between 20 to 30 ng/mL and patient adherence established (Step 1 increase):

Infants: Oral: 800 to 1,000 units (20 to 25 mcg) once daily.

Children ≤10 years: Oral: 1,600 to 3,000 units (40 to 75 mcg) once daily.

Children >10 years and Adolescents: Oral: 1,600 to 6,000 units (40 to 150 mcg) once daily.

Dosing adjustment for serum 25(OH)D level <20 ng/mL or persistently between 20 to 30 ng/mL and patient adherence established (Step 2 increase):

Infants: Oral: Increase up to a maximum 2,000 units (50 mcg) once daily.

Children ≤10 years: Oral: Increase to a maximum of 4,000 units (100 mcg) once daily.

Children >10 years and Adolescents: Oral: Increase to a maximum of 10,000 units (250 mcg) once daily.

Alternate dosing (Hall 2010):

Initial dose: Serum 25(OH)D level ≤30 ng/mL.

Infants: Oral: 8,000 units (200 mcg) once weekly.

Children and Adolescents: Oral: 800 units (20 mcg) once daily.

Medium-dose regimen: Serum 25(OH)D level remains ≤30 ng/mL and patient compliance established.

Infants and Children <5 years: Oral: 12,000 units (300 mcg) once weekly for 12 weeks.

Children ≥5 years and Adolescents: Oral: 50,000 units (1,250 mcg) once weekly for 12 weeks.

High-dose regimen: Repeat 25(OH)D level remains ≤30 ng/mL and patient compliance established.

Infants and Children <5 years: Oral: 12,000 units (300 mcg) twice weekly for 12 weeks.

Children ≥5 years and Adolescents: Oral: 50,000 units (1,250 mcg) twice weekly for 12 weeks.

Vitamin D insufficiency or deficiency associated with CKD, treatment; serum 25 hydroxyvitamin D [25(OH)D] level ≤30 ng/mL

Vitamin D insufficiency or deficiency associated with CKD (stages 2 to 5, 5D), treatment; serum 25 hydroxyvitamin D [25(OH)D] level ≤30 ng/mL (KDOQI Guidelines 2009):

Serum 25(OH)D level 16 to 30 ng/mL: Infants, Children, and Adolescents: Oral: 2,000 units (50 mcg) daily for 3 months or 50,000 units (1,250 mcg) every month for 3 months.

Serum 25(OH)D level 5 to 15 ng/mL: Infants, Children, and Adolescents: Oral: 4,000 units (100 mcg) daily for 12 weeks or 50,000 units (1,250 mcg) every other week for 12 weeks.

Serum 25(OH)D level <5 ng/mL: Infants, Children, and Adolescents: Oral: 8,000 units (200 mcg) daily for 4 weeks then 4,000 units (100 mcg) daily for 2 months for total therapy of 3 months or 50,000 units (1,250 mcg) weekly for 4 weeks followed by 50,000 units (1,250 mcg) 2 times/month for a total therapy of 3 months.

Maintenance dose [once repletion accomplished; serum 25(OH)D level >30 ng/mL]: Infants, Children, and Adolescents: Oral: 200 to 1,000 units (5 to 25 mcg) daily.

Nutritional rickets, treatment

Nutritional rickets, treatment: Limited data available (Munns 2016): Administer in combination with calcium supplementation:

Daily therapy (preferred):

Infants: Oral: 2,000 units (50 mcg) daily for ≥3 months, followed by maintenance dose of 400 units (10 mcg) daily.

Children: Oral: 3,000 to 6,000 units (75 to 150 mcg) daily for ≥3 months, followed by maintenance dose of 600 units (15 mcg) daily.

Adolescents: Oral: 6,000 units (150 mcg) daily for ≥3 months, followed by maintenance dose of 600 units (15 mcg) daily.

Single-dose therapy:

Infants ≥3 months: Oral: 50,000 units (1,250 mcg) once, or in divided doses over several days; after 3 months, initiate maintenance dose of 400 units (10 mcg) daily.

Children: Oral: 150,000 units (3,750 mcg) once, or in divided doses over several days; after 3 months, initiate maintenance dose of 600 units (15 mcg) daily.

Adolescents: Oral: 300,000 units (7,500 mcg) once, or in divided doses over several days; after 3 months, initiate maintenance dose of 600 units (15 mcg) daily.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, cholecalciferol is not renally eliminated to a significant extent and dosage adjustment is not necessary.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Adult

(For additional information see "Vitamin D3 (cholecalciferol): Drug information")

Note: 1 mcg = 40 units

Osteoporosis prevention

Osteoporosis prevention (off-label use): Adults ≥50 years of age: Oral: 800 to 1,000 units/day (20 to 25 mcg/day) is recommended, through dietary sources and/or supplementation if needed (NOF [Cosman 2014]).

Vitamin D insufficiency/deficiency

Vitamin D insufficiency/deficiency (off-label use):

Note: The optimal serum 25-hydroxyvitamin D (25[OH]D) level has not been established; generally, deficiency is defined as 25(OH)D levels <12 ng/mL (<30 nmol/L), and insufficiency is defined as 25(OH)D levels 12 to <20 ng/mL (30 to <50 nmol/L) (Giustina 2019). Therefore, some experts suggest a target range of 20 to 40 ng/mL (50 to 100 nmol/L) for most patients (Dawson-Hughes 2022). Individualize dose based on patient-specific factors (eg, presence of malabsorption, liver disease, kidney disease) and target 25(OH)D level and ensure adequate calcium intake during therapy (Dawson-Hughes 2022; NOF [Cosman 2014]). The following recommendations are based primarily on expert opinion and clinical experience:

Prevention:

Oral: 600 to 1,000 units (15 to 25 mcg) once daily (IOM 2011; NOF [Cosman 2014]).

Treatment:

Initial dosing:

High-dose therapy: May be preferred in patients with a serum 25(OH)D level <12 ng/mL (<30 nmol/L) or who are symptomatic (eg, bone fracture/pain, muscle weakness), or in patients with concomitant hypocalcemia (Dawson-Hughes 2022; Goltzman 2022; NOF [Cosman 2014]).

Oral: 50,000 units (1,250 mcg) once weekly (or equivalent dose administered once daily) for 6 to 12 weeks, then recheck 25(OH)D level; may repeat high-dose therapy if needed to achieve target 25(OH)D level (Dawson-Hughes 2022; Goltzman 2022; NOF [Cosman 2014]).

Low-dose therapy: May be preferred in patients with a serum 25(OH)D level 12 to <20 ng/mL (30 to <50 nmol/L) without symptoms or concomitant hypocalcemia (Dawson-Hughes 2022).

Oral: 800 to 1,000 units (20 to 25 mcg) once daily for ~3 to 4 months; may adjust dose if needed every 3 to 4 months based on 25(OH)D level. Some experts suggest modest dose increases (eg, to 2,000 units [50 mcg] once daily) if serum 25(OH)D levels have substantially increased but remain below target or switching to high-dose therapy if serum 25(OH)D levels remain substantially below target (Dawson-Hughes 2022).

Maintenance dosing: Oral: Once target 25(OH)D level is achieved, continue at a maintenance dose of 600 to 2,000 units (15 to 50 mcg) once daily (Dawson-Hughes 2022; NOF [Cosman 2014]).

Special populations (eg, obesity, patients on medications known to affect vitamin D metabolism, malabsorption, gastrectomy): Higher doses or longer durations may be necessary for adequate replacement. In patients with malabsorption when target 25(OH)D levels cannot be maintained with cholecalciferol, consider switching to hydroxylated vitamin D metabolites (eg, calcitriol) (Brandi 2013; Dawson-Hughes 2022).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Note: In patients with chronic kidney disease (CKD) G3a to G5D, Kidney Disease: Improving Global Outcomes guidelines recommend correcting vitamin D deficiency and insufficiency with treatment strategies recommended for patients without kidney impairment. In patients with CKD G4 to G5 with severe and progressive hyperparathyroidism despite correction of modifiable factors (eg, hyperphosphatemia, vitamin D deficiency), calcitriol or vitamin D analogs are suggested (Ref).

Altered kidney function: No dosage adjustment necessary for any degree of kidney dysfunction (primarily excreted in feces) (Ref).

Hemodialysis, intermittent (thrice weekly): Unlikely to be significantly dialyzed (large Vd): No supplemental dose or dosage adjustment necessary (Ref).

Peritoneal dialysis: Unlikely to be significantly dialyzed (large Vd): No dosage adjustment necessary (Ref).

CRRT: No dosage adjustment necessary (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration): No dosage adjustment necessary (Ref).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

No adverse reactions listed in the manufacturer's labeling.

Contraindications

US labeling: OTC labeling: Replesta products only: When used for self-medication, do not use if you have hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D, Williams syndrome, or are pregnant.

Canadian labeling: Hypersensitivity to vitamin D, vitamin D analogues and derivatives, or any component of the formulation, hypercalcemia and/or hypercalciuria, nephrolithiasis, severe kidney impairment, malabsorption syndrome, abnormal sensitivity to toxic effects of vitamin D, sarcoidosis, or hypervitaminosis D. Note: Contraindications may vary by product; also refer to manufacturer's labeling.

Warnings/Precautions

Concerns related to adverse effects:

• Vitamin D toxicity: May occur with excessive doses; symptoms may include nausea, vomiting, loss of appetite, constipation, dehydration, fatigue, irritability, confusion, weakness and/or weight loss. Effects of vitamin D can last ≥2 months after therapy is discontinued.

Disease related concerns:

• Hyperphosphatemia: Normal serum phosphorous concentrations must be maintained in patients treated for hyperphosphatemia to prevent metastatic calcification.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP 1997; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates. See manufacturer's labeling.

• Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson 2002; Lucente 2000; Shelley 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade 1986; CDC 1984). See manufacturer's labeling.

• Propylene glycol: Some dosage forms may contain propylene glycol; large amounts are potentially toxic and have been associated hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution (AAP 1997; Zar 2007). See manufacturer's labeling.

Warnings: Additional Pediatric Considerations

Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution (AAP, 1997; Shehab, 2009).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

D3-50: 1250 mcg (50000 unit) [dairy free, egg free, fish derivative free, gluten free, kosher certified, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

Decara: 1250 mcg (50000 unit) [contains fd&c yellow #6 (sunset yellow), quinoline yellow (d&c yellow #10), soybean oil]

Decara: 250 mcg (10000 unit) [DSC] [contains fd&c yellow #6(sunset yellow)alumin lake, gelatin (bovine), quinoline (d&c yellow #10) aluminum lake]

Decara: 625 mcg (25000 unit) [contains soybean oil]

Dialyvite Vitamin D 5000: 125 mcg (5000 unit)

Pronutrients Vitamin D3: 25 mcg (1000 unit) [contains soybean oil]

True Vitamin D3: 10 mcg (400 unit), 1250 mcg (50000 unit), 250 mcg (10000 unit), 125 mcg (5000 unit), 25 mcg (1000 unit)

Vitamin D3: 250 mcg (10000 unit) [contains fd&c blue #1 (brilliant blue), quinoline yellow (d&c yellow #10), soybean oil]

Vitamin D3: 1250 mcg (50000 unit) [contains gelatin (bovine), soybean oil]

Vitamin D3: 250 mcg (10000 unit) [contains soybean oil]

Vitamin D3: 1250 mcg (50000 unit) [egg free, kosher certified, milk derivatives/products, soy free, wheat free]

Vitamin D3: 250 mcg (10000 unit) [gluten free; contains soybean oil]

Vitamin D3: 50 mcg (2000 unit) [no artificial color(s), no artificial flavor(s); contains gelatin (bovine), soybean oil]

Weekly-D: 1250 mcg (50000 unit) [contains fd&c red #40 (allura red ac dye)]

Capsule, Oral [preservative free]:

D-3-5: 125 mcg (5000 unit) [dairy free, dye free, egg free, gluten free, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

D3-50: 1250 mcg (50000 unit) [dairy free, egg free, fish derivative free, gluten free, kosher certified, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

Vitamin D3: 50 mcg (2000 unit) [DSC] [gluten free, milk derivatives/products, no artificial color(s), no artificial flavor(s), sodium free, soy free, starch free, sugar free, yeast free]

Vitamin D3: 125 mcg (5000 unit) [gluten free, no artificial color(s), no artificial flavor(s), starch free, sugar free, wheat free, yeast free; contains soybean oil]

Vitamin D3: 50 mcg (2000 unit) [gluten free, no artificial color(s), no artificial flavor(s), sugar free, wheat free, yeast free; contains soybean oil]

Vitamin D3: 25 mcg (1000 unit) [gluten free; contains soybean oil]

Generic: 10,000 units

Liquid, Oral:

Aqueous Vitamin D: 10 mcg/mL (400 unit/mL) (50 mL) [gluten free, lactose free, sugar free; contains corn oil, methylparaben, polysorbate 80]

BProtected Pedia D-Vite: 10 mcg/mL (400 unit/mL) (50 mL) [alcohol free, sugar free; contains polysorbate 80, propylene glycol, sodium benzoate; cherry flavor]

D-Vi-Sol: 10 mcg/mL (400 unit/mL) (50 mL) [gluten free, lactose free, sugar free; contains polysorbate 80]

D-Vite Pediatric: 10 mcg/mL (400 unit/mL) (50 mL) [alcohol free, gluten free, lactose free, no artificial color(s), sugar free; contains disodium edta, polysorbate 80, propylene glycol, saccharin sodium, sodium benzoate]

Osteo-Vit3: 417 mcg/mL (15 mL)

Vitamin D3: 10 mcg/mL (400 unit/mL) (52 mL) [gluten free; contains soybean oil; lemon flavor]

Generic: 10 mcg/mL (400 unit/mL) (50 mL)

Liquid, Oral [preservative free]:

Vitamin D3: 125 mcg/mL (5000 unit/mL) (52 mL) [gluten free, no artificial color(s), no artificial flavor(s), starch free, sugar free, wheat free, yeast free; contains corn oil, soybean oil; lemon flavor]

Liquid, Sublingual:

Generic: 125 mcg/mL (5000 units/mL) (60 mL [DSC])

Tablet, Oral:

Delta D3: 10 mcg (400 unit) [gelatin free, gluten free, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Dialyvite 5000: 5 mg

Dialyvite Vitamin D3 Max: 1250 mcg (50000 unit) [scored]

True Vitamin D3: 10 mcg (400 unit), 1250 mcg (50000 unit), 250 mcg (10000 unit), 125 mcg (5000 unit), 25 mcg (1000 unit)

Vitamin D3: 10 mcg (400 unit), 250 mcg (10000 unit), 75 mcg (3000 unit), 50 mcg (2000 unit) [DSC], 25 mcg (1000 unit), 20 mcg (800 unit)

Vitamin D3: 125 mcg (5000 unit) [animal products free, gelatin free, gluten free, kosher certified, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Vitamin D3: 25 mcg (1000 unit) [gelatin free, gluten free, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Vitamin D3: 10 mcg (400 unit), 125 mcg (5000 unit), 50 mcg (2000 unit), 25 mcg (1000 unit) [gluten free]

Vitamin D3: 25 mcg (1000 unit) [scored; gluten free]

Vitamin D3 Ultra Potency: 1250 mcg (50000 unit)

Generic: 10 mcg (400 unit), 25 mcg (1000 unit), 50 mcg (2000 unit) [DSC]

Tablet, Oral [preservative free]:

Vitamin D3: 10 mcg (400 unit) [corn free, no artificial color(s), no artificial flavor(s), starch free, sugar free, wheat free, yeast free]

Vitamin D3: 25 mcg (1000 unit) [egg free, fish derivative free, milk free, no artificial color(s), no artificial flavor(s), nut free, peanut free, shellfish free, yeast free]

Vitamin D3: 50 mcg (2000 unit) [egg free, milk free, no artificial color(s), no artificial flavor(s), nut free, peanut free, shellfish free, yeast free]

Vitamin D3: 10 mcg (400 unit) [gluten free]

Vitamin D3: 10 mcg (400 unit), 25 mcg (1000 unit) [no artificial color(s), no artificial flavor(s), starch free, sugar free]

Generic: 5000 units, 25 mcg (1000 unit) [DSC], 50 mcg (2000 unit) [DSC]

Tablet Chewable, Oral:

VitaChew Vitamin D3: 25 mcg (1000 unit) [dairy free, gluten free, no artificial color(s), no artificial flavor(s), nut free, soy free; contains coconut oil (copra/cocos nucifera oil)]

Vitamin D3: 10 mcg (400 unit) [gluten free]

Tablet Chewable, Oral [preservative free]:

Vitamin D3: 50 mcg (2000 unit) [gluten free, no artificial color(s), no artificial flavor(s)]

Generic Equivalent Available: US

Yes

Pricing: US

Capsules (D3-50 Oral)

1.25 MG(50000 UT) (per each): $0.21

Capsules (Decara Oral)

1.25 MG(50000 UT) (per each): $1.19

625 MCG(25000 UT) (per each): $1.91

Capsules (Dialyvite Vitamin D 5000 Oral)

125 MCG(5000 UT (per each): $0.13

Capsules (Pronutrients Vitamin D3 Oral)

25 MCG(1000 UT) (per each): $0.07

Capsules (Weekly-D Oral)

1.25 MG(50000 UT) (per each): $1.10

Liquid (BProtected Pedia D-Vite Oral)

10 mcg/mL (per mL): $0.18

Liquid (D-Vi-Sol Oral)

10 mcg/mL (per mL): $0.20

Tablets (Dialyvite 5000 Oral)

5 mg (per each): $0.56

Tablets (Dialyvite Vitamin D3 Max Oral)

1.25 MG(50000 UT) (per each): $1.08

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Generic: 1250 mcg (50000 unit), 250 mcg (10000 unit), 50 mcg (2000 unit)

Tablet, Oral:

Generic: 250 mcg (10000 unit)

Additional Information

1 mcg cholecalciferol provides 40 units of vitamin D activity

Biological potency may be greater with cholecalciferol (vitamin D3) compared to ergocalciferol (vitamin D2).

Administration: Pediatric

Oral: May be administered without regard to meals; for oral liquid, administer with an accurate measuring device; do not use a household teaspoon (overdosage may occur).

Administration: Adult

Oral: Wafers: Chew or crush before swallowing; do not swallow wafer whole; administer with the largest meal of the day.

Storage/Stability

Store at 15°C to 30°C (59°F to 86°F); do not freeze. Protect from light.

Use

Prevention and treatment of vitamin D deficiency and/or rickets; dietary supplement (FDA approved in all ages).

Medication Safety Issues
Sound-alike/look-alike issues:

Cholecalciferol may be confused with alfacalcidol, ergocalciferol

Administration issues:

Liquid vitamin D preparations have the potential for dosing errors when administered to infants. Droppers should be clearly marked to easily provide 400 units. For products intended for infants, the FDA recommends that accompanying droppers deliver no more than 400 units per dose.

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Bile Acid Sequestrants: May decrease the serum concentration of Vitamin D Analogs. More specifically, bile acid sequestrants may impair absorption of Vitamin D Analogs. Management: Avoid concomitant administration of vitamin D analogs and bile acid sequestrants (eg, cholestyramine). Separate administration of these agents by several hours to minimize the potential risk of interaction. Monitor plasma calcium concentrations. Risk D: Consider therapy modification

Calcium Salts: May enhance the adverse/toxic effect of Vitamin D Analogs. Risk C: Monitor therapy

Cardiac Glycosides: Vitamin D Analogs may enhance the arrhythmogenic effect of Cardiac Glycosides. Risk C: Monitor therapy

Danazol: May enhance the hypercalcemic effect of Vitamin D Analogs. Risk C: Monitor therapy

Erdafitinib: Serum Phosphate Level-Altering Agents may diminish the therapeutic effect of Erdafitinib. Management: Avoid coadministration of serum phosphate level-altering agents with erdafitinib before initial dose increase period based on serum phosphate levels (Days 14 to 21). Risk D: Consider therapy modification

Mineral Oil: May decrease the serum concentration of Vitamin D Analogs. More specifically, mineral oil may interfere with the absorption of Vitamin D Analogs. Management: Avoid concomitant, oral administration of mineral oil and vitamin D analogs. Consider separating the administration of these agents by several hours to minimize the risk of interaction. Monitor plasma calcium concentrations. Risk D: Consider therapy modification

Multivitamins/Fluoride (with ADE): May enhance the adverse/toxic effect of Vitamin D Analogs. Risk X: Avoid combination

Multivitamins/Minerals (with ADEK, Folate, Iron): May enhance the adverse/toxic effect of Vitamin D Analogs. Risk X: Avoid combination

Orlistat: May decrease the absorption of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or 2 hours after the administration of orlistat. Avoid concomitant administration due to the risk of impaired vitamin absorption. Risk D: Consider therapy modification

Thiazide and Thiazide-Like Diuretics: May enhance the hypercalcemic effect of Vitamin D Analogs. Risk C: Monitor therapy

Vitamin D Analogs: May enhance the adverse/toxic effect of other Vitamin D Analogs. Risk X: Avoid combination

Dietary Considerations

Vitamin D is found in egg yolks, fatty fish, fortified milk, fortified cereal, and infant formulas; it is also produced by exposure to sunlight (IOM 2011).

Dietary Reference Intake for Vitamin D (IOM 2011):

0 to 12 months: Adequate intake: 10 mcg/day (400 units/day)

1 to 70 years: RDA: 15 mcg/day (600 units/day)

>70 years: RDA: 20 mcg/day (800 units/day)

Pregnancy/Lactating: RDA: 15 mcg/day (600 units/day)

Pregnancy Considerations

The cholecalciferol metabolite, 25(OH)D, crosses the placenta; maternal serum concentrations correlate with fetal concentrations at birth (Misra 2008; Wagner 2008).

Adequate maternal vitamin D is required for fetal growth and development (Misra 2008). Vitamin D deficiency in a pregnant woman may lead to a vitamin D deficiency in the neonate (Misra 2008; Wagner 2008). Serum 25(OH)D concentrations should be measured in pregnant women considered to be at increased risk of deficiency (ACOG 2011). The amount of vitamin D contained in prenatal vitamins may not be adequate to treat a deficiency during pregnancy; although larger doses may be needed, current guidelines recommend a total of 1,000 to 2,000 units/day (25 to 50 mcg/day) until more safety data is available (ACOG 2011). In women not at risk for deficiency, doses larger than the RDA should be avoided during pregnancy (ACOG 2011; IOM 2011).

Monitoring Parameters

Children at increased risk of vitamin D deficiency (chronic fat malabsorption, chronic antiseizure medication use) require serum 25(OH)D, PTH, and bone-mineral status to evaluate. If vitamin D supplement is required, then 25(OH)D levels should be repeated at 3-month intervals until normal. PTH and bone mineral-status should be monitored every 6 months until normal.

Chronic kidney disease: Monitor serum 25(OH)D, corrected total calcium and phosphorus levels 1 month following initiation of therapy, every 3 months during therapy and with any Vitamin D dose change; alkaline phosphatase, BUN

Reference Range

Vitamin D status may be determined by serum 25(OH)D levels (Misra 2008):

Severe deficiency: ≤5 ng/mL (12.5 nmol/L)

Deficiency: 15 ng/mL (37.5 nmol/L)

Insufficiency: 15 to 20 ng/mL (37.5 to 50 nmol/L)

Sufficiency: 20 to 100 ng/mL (50 to 250 nmol/L)*

Excess: >100 ng/mL (250 nmol/L)**

Intoxication: 150 ng/mL (375 nmol/L)

*Based on adult data a level of >32 ng/mL (80 nmol/L) is desirable

**Arbitrary designation

Target serum 25(OH)D: >30 ng/mL

Mechanism of Action

Cholecalciferol (vitamin D3) is a provitamin. The active metabolite, 1,25-dihydroxyvitamin D (calcitriol), stimulates calcium and phosphate absorption from the small intestine, promotes secretion of calcium from bone to blood; promotes renal tubule phosphate resorption (IOM 2011)

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Absorbed in the small intestine; fat soluble; requires bile (IOM 2011).

Distribution: Vd/F: Adult: 237 L (Benaboud 2012).

Metabolism: Inactive until hydroxylated hepatically to 25-hydroxyvitamin D [25(OH)D; calcifediol] then renally to the active metabolite 1,25-dihydroxyvitamin D (calcitriol) (IOM 2011).

Half-life, circulating: 25(OH)D: 2 to 3 weeks; 1,25-dihydroxyvitamin D: ~4 hours.

Excretion: Feces (IOM 2011).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Ams vitamin d3 | Biodal | D trol | D3 fix | Dferol | Dibase | Ditamin adulvit | Ditamin babyvit D | Divad | Euro D | Fresh d | Growlyn d | Hi dee | Jamieson d3 | Nature made kids d3 | Nature's bounty d3 | Nordic naturals baby's vitamin d3 | Pediavit d | Puritan's pride sunvite mega potency vitamin d3 | Suntabs | Ultra D | Ultra vitamin d | Ultra vitamin d3 | Vidal d3 | Vidrop | Vit d3 | Vita link vitamin d3 | Vitamin d | Vitamin d3 | Vitamin d3 streuli | Vitrunova liposomal vitamin D3 | Wellbaby vit d;
  • (AR) Argentina: Calcitol D3 | Crada | Deblax | Devisal cb | Dia d | Gadoferol cb | Invita d3 | Natuliv vitamina D | Nuctis d | Oravil | Osteodyn | Raquiferol d3 | Sterogyl | Sterogyl 1000 | Testri | Trevix | Trip d3 | Vitamina d3 | Vitamina d3 garden;
  • (AT) Austria: Dekristolmin | Divisun | Gerovit d3 | Laevovit d3 | Oleo d3 | Vi-De 3 | Vitamin d3 agepha;
  • (AU) Australia: Amcal ostetab | Amcal vitamin D | Amplio d3 with coconut oil | Bayer citracal vitamin d | Bio Logical Vitamin D | Bioglan Bioactive Vitamin D | Bioglan vitamin d3 | Blooms vitamin d3 | Brauer Baby & Kids Liquid Vitamin D | Brauer Kids Liquid Vitamin D | Brauer kids vitamin d | Caruso's ultra max vitamin d3 | Caruso's vitamin d3 | Cenovis vitamin d3 | Cholecalciferol | Clear vitamin d3 | D3 | D3 5000 | Ddrops | Eagle vitamin d3 | Ethical nutrients daily d | Faulding kids vitamin d | Go vitamin d3 | JSHealth Vitamin D+ | Living healthy vitamin d3 | Metagenics vitamin d3 | Microgenics Vitamin D3 | Nature's Way kids smart vitamin d3 | Natures own vitamin D3 | Natures sunshine vitamin d3 | Naturopathica vegan vitamin d | Nourex Professional Vitamin D | Nourex professional vitamin d3 forte | Orthoplex Vitamin D | Ostelin kids vitamin d3 | Ostelin vitamin d | Ostelin vitamin d3 | Osteo d3 | Ostevit D | Ostevit d one a week | Oviit vitamin d 1000 | Ozmed vitamin d3 | Pharmacist Formula Vitamin D | Pharmacy action vitamin d | Quality health vitamin d | Sup d ficient | Swisse kids vitamin d3 liquid | Swisse Ultiboost Vitamin D | Swisse Ultinatal Vitamin D3 | Trust osteo d | Trust vitamin d3 | Ultra nature vitamin d3 | Vita D | Vital d3 | Vitamax Vitamin D3 | Vitamin d | Vitamin d3 | VitaScience Vitamin D3 | Voost vitamin d;
  • (BD) Bangladesh: Calciferol | D balance | D cap | D revive | D rise | D star | D vine | D3 | Defrol | Ditarol | Hi-d | Maxd | Ortho d3 | Osteo d | Sun d | Vita d3 | Vital d;
  • (BE) Belgium: D cure | D ixX | D tri | Fultivit d3 | Thorens | Vibosun d3 | Vitamine d will;
  • (BG) Bulgaria: Deavit neo | Soligamma | Vitamin d3 krka;
  • (BR) Brazil: Addera d3 | Adecol d3 | Aderofix d | Alta d | Altad | Aporte d3 | Atitud | Ativesse vitamina d | B-well vitamina d | Colecalciferol d3 | Copra d3 | Cronoliv vitamina d3 | Cronovit vitamina d | Cygnus d | D max | D nova | D pro | D san | D valle | D+nutry | D.nova D3 | D200 | D2000 | D3 | D3 mais | D3caps | Damater d | Day d3 | Defixa | Deforce | Defull | Degen | Delumi | Demi d | Depura | Depura kids | Desol | Desupre d3 | Detem d3 | Devera | Devit | Deviter | Doss | Dphar | Dprev | Dprev todo dia | Dropy d | Dviter | Dviterd3 | Dvitta | EssenceVit vitamina D | Excivit d | Fixsol d | Forthiben vitamina d | Gran d | Inpruv d | Koli d3 | Life vitamina d | Maisol | Maisol vit | Maxxi d3 | Medvitd3 | Mide d3 | Milde | Multifort d3 | Multivit d3 kids | Natumed vitamina d | Neshde | Nutride maxx | Ohde | Ohde caps | Petivit d3 kids | Plex d3 vitamin | Pro d max | Provicta d | Proway vitamina d | Raia vitamina d3 | Rarivit d | Renoforce vitamina d | Reumatrite d | Sany d | Sidney oliveira vitamina d | Simpli d | Sobralvit | Sof d | Start d | Sun d3 maxx | Super D3 | Tresde | Tridevit | Trynde | Tua d | Ultra d3 | Veg d | Vidyn d3 | Vit d | Vit d3 | Vit sunny d3 | Vita d plus | Vita d3 | Vitacon d | Vital d | Vitamin d3 | Vitamina d | Vitamina d 3 | Vitamina d cimed | Vitamina d max | Vitamina d star | Vitamina d3 | Vitamina d3 isolada | Vitax D3 | Vitd3 | Vitdera d | Vitdera d3 | Vitersol d | Vitersol dm | Vitgold vitamin d3 | Vitta d kids | Vitta d3 | VittaD kids;
  • (CH) Switzerland: Burgerstein vitamin d3 | Dibase | Lundeos | Luvit d3 | Vi-De 3 | Vita d3 | Vitamin d3 | Vitamin d3 sandoz | Vitamin D3 spirig HC | Vitamin d3 streuli | Vitamin D3 Wild;
  • (CL) Chile: Acuode | Altad | Bonavid | D vida | D VIDA MAX | D'vida | Deblax | Detres | Inforvit | Mi vit d | Osteodyn | Osteonova | Summavit | Sunrise D | Vitamina d3 | Vitde;
  • (CN) China: Nature's bounty d3 | Vitamin d3;
  • (CO) Colombia: Deblax | Deferol | Farma D | Nuctis d | Nuevid | Osteoferol | Sun vita d3 | Vita D | Vitamin d3 | Vitamina d3;
  • (CZ) Czech Republic: Fultium d3 | Olvit d3 | Vigantol | Vitamin d | Vitamin d3 axonia;
  • (DE) Germany: Abtei vitamin d3 | Additiva osteogard | Ankubero vitamin D3 | Aov Vitamin D3 | Aponeo vitamin d3 | Aportha vitamin d3 | Apovital osteoporose | Apovital vitamin d | Arktis vita d | Bakanasan vitamin d3 | Bio D Mulsion | Biolabor osteovit | Biolabor vitamin d3 | Bionovelia vitamin d3 | Cc Vital Vitamin D | Cefavit d3 | Centax vitamin d3 | Cholecalciferol ratiopharm | Clives vitamin d3 | Colecalciferol Aristo | Cosphera vitamin d3 | Cyb vitamin d3 | D 10 | D 25 | D 50 | D max | D max kids | D mulsin | D trol | D3 actif | D3 active denk | D3 vicotrat | Decurol | Dedrei | Dekristol | Dekristolvit d3 | Devit | Dino D | Doppelherz pure vitamin d3 | Doppelherz vitamin d3 | Doppelherz vitamine D3 | Echt vital vitamin d3 | Encormed vitamin d3 | Esn vitamin d3 | Immundoc vitamin D | Kito hfp d3 | LiquidVitamin D3 | Livsane vitamin d | Medicon vitamin d3 | Meta care d3 | Naturafit vitamin d3 | Naturkraft D3 | Neamin d3 | Neovel med vitamin d3 | Nicapur vitamin d3 | Ntm d | Nutramin D 3000 forte | Nutritheke Vitamin D3 | Oekothek vit d3 1000 | Orthodoc vitamin d3 | Ospur d3 | Osteofit Mono D | Phytholistic vitamin d3 | Plus vitamin d | Probio vitamin d3 | Pure encapsulations vitamin d3 | Robert franz vitamin d3 | Rokivit d3 | SalutomedD3 | Sanotact vitamin d3 | Taxofit vitamin d3 | Tetesept vitamin d3 | Tri.balance vitamin d3 | Ultra d3 | Vigantol | Vigantoletten | Vigantolvit | Vigorsan | Vit d3 biosyn | Vita d3 | Vitagamma | Vitamin d | Vitamin D Loges | Vitamin d plus | Vitamin d sandoz | Vitamin D Sovita | Vitamin D Support | Vitamin d verla | Vitamin d3 | Vitamin d3 1000 | Vitamin D3 Apologo | Vitamin d3 flussig | Vitamin D3 Medicom | Vitamin D3 Ol | Vitamin D3 plus | Vitamin D3 Sonnenvitamin | Vitamin d3 vida | Vitamin d3-hevert | Vitammin d3 daily | Vitapas d | Vitaplace vitamin D3 | Wellbaby vitamin d;
  • (DK) Denmark: Camette D3 | Livol d3;
  • (DO) Dominican Republic: D3 | Deblax | Derovit | Detres | Diglet | Nature's bounty d3 | Triamin | Ultra D 3;
  • (EC) Ecuador: Alta d | Deblax | Deferol | Devisal cb | Farma D | Herbalmax vitamina d3 | Nature's bounty d3 | Nuctis d | Vitamin d3 | Vitamina d3;
  • (EE) Estonia: A. vitamiin d3 | Apovit d-vitamin | Apovit D3 | Apovit d3 forte plus | Bertils vitamin d3 | Biocare biomulsion d | D max | D paerlid | D Vitamiini | D-staerk | D3 vitamiin | D3 vitamiini | D3 vitamin | Dstrong | Ecosh d3 vitamiin | Forday vitamin d3 | Jamieson chewable D3 | Kids+ D400 | Livsane d3 | Minisun | Minisun d3 vitamin | Minisun d3-vitamiini | Minisun vitamin d3 | Muumi d-vitamiin | Now vitamin d 3 | Oilesen forte d3 | Oilesen vitamin d3 | Olvels vitamins d3 | Pro expert vitamin d3 | Room vitamiin d3 | Smarthit iv vitamin D3 | Solvitale vitamin d3 | Tervisepuramiid vitamiin d3 | Tervisepuramiid vitamin d3 | Ultra vitamin d | Videral | Vitamiin d paikese | Vitamin d | Vitamin d3 | Vitatabs D tipat | Vitatabs Puru D;
  • (EG) Egypt: Copad 10000 | D trol | D3 | Davalindi | Devodanad | Immuno mash d | Nutritru d | Sanso d3 | Thimepro d3 | Vidrop | Vitamin d3;
  • (ES) Spain: Benferol | Colecalciferol rovi | Colecalciferol teva | Dekristolan | Delcrin | Deltius | Devik | Disbron | Divisun | Lundeos | Thorens | Vitamina d3 berenguer | Vitamina d3 farmasierra | Vitamina d3 nm;
  • (FI) Finland: Benferol | Deetipat | Detremin | Detrixin | Divifarm | Divisun | Fultium | Jekovit d3;
  • (FR) France: Adrigyl | Deltius | Ergy d plus | Kipos | Uvecaps | Uvedose | Zymad;
  • (GB) United Kingdom: Aciferol d3 | Aviticol | Colekal d3 | Colevit D3 | Dekristol | Desunin | Fultium d3 | HuxD3 | Invita d3 | Plenachol | Pro d3 | Reflex nutrition vitamin d3 | Sapvit d3 | Solgar vitamin d3 | Stexerol d3 | Strivit d3 | Synbio vitamin d3 | Thorens | Vitamin d3;
  • (GR) Greece: Calcifenov | D vit3 | D-triol | D3 ben | D3 fix | D3zac | Dasolan s | Deltius | Gnostormon | Lecalcif;
  • (HK) Hong Kong: Baby ddrops | Doctor's choice vitamin d3 | Vitamin d | Vitamin d3;
  • (HR) Croatia: D vital | Oleovit d3 | Plivit d3;
  • (HU) Hungary: D3 vitamin | D3 vitamin beres | D3 vitamin meditop | Eurovit d-vitamin | Jutavit d3 vitamin | Laevovit d3 | Vigantol | Vitamin d3 | Vitamin D3 Fresenius;
  • (ID) Indonesia: Alphacare vit d3 | Boost d | Citamin d3 | Comvit d | D vit | Detrivit | Doctor's best vitamin d3 | Dtrivit | Force D | Forti d | Fortiboost d3 | Good life vit d | Gp fit d3 | H2 vit d3 | Halowell d3 | Healthy care vitamin d3 | Konilife d1000 | L vit D3 | Mecovit d3 | Mega nat d | Natureline kids vitamin d3 | Natureline vitamin d3 | Now vitamin d3 | Nu health vitamin d3 | Nutrahealth vitamin d3 | Nuvita nutri d3 | Osteosan | Oxyvit d3 | Pehavit d3 | Provigen | Pyfahealth vitamin d3 | Solvita D | Solvitral | Sunvite vitamin d3 | Swisse Ultiboost Vitamin D | Treelains vitamin d3 | Ultra vitamin d | Vitalife d3 | Vitamin D3 ipi | Well3 d3;
  • (IE) Ireland: Adult D3 | Dekristol | Desunin | Fultium d3 | Solferol | Sona D1000 | Sona Infant D3 | Thorens | Vigantoletten | Zymad;
  • (IL) Israel: Tiptipot vitamin d3 | Vitamidyne D;
  • (IN) India: Acorise d3 | Add3 | Adferol | Adtrol D | Aktiv d | Al d3 | Alefol d3 | All sun d60 | App d3 | AquaD3 | Arachitol | Arachitol nano | Arbivit 3 | Bigrise | Biobond d3 | Bioferol d3 | Bon Dk | Bonovite d3 | Calci-Best | Calcifit d | Calcirol | Calcitas d3 | Caldemure d3 | Calex | Calocal d3 | Caloshell d3 | Calsal | Caly d3 | Carvical d3 | Cholical | Cholvac d3 | Citrol d3 | Coed3 | Com d3 drops | Con osteo | D 360 | D bright | D first nano | D flik | D gain | D liq | D Liq Max | D retcal | D rise | D shine | D Sol | D tamin | D up | D wik | D3 120 | D3 bon | D3 hd | D3 kind | D3 more | D3 must | D3 pil | D3 rich | D3 Shot | D3 sure | D3 total | D3 Up | D3 veda | D3sol | Daily shine | Dboost | Ddd Cholecalciferol (vitamin d3) | Dee3 60K | Deeammrit | Deksel | Depocal | Depura | Desix | Detriol | Dhup | Dio 60 k tab | Dsential | DV 60K | Dvion | Dvital | Dweet 3 | Ecomune d3 | Elcad | Eldervit d3 | Ercal d | Esd3 | Eucal d3 | Evd3 | Evecalcirol | Ex d3 | Fdc d3 | Fosamin | Galrol | Gen D3 | Gen d3 nano | Geri d3 | Goldcal d3 | Hk vitals vitamin d3 | Hnu d3 | Innov d3 | Inoplex d3 | Isi d3 | Jusdee | Klm d3 | Lax d3 | Loy d3 | Lumia 60K | Lupi d3 | Macbrite D3 | Mashyne | Max d3 | Mdbond | Methycal | Micro d3 | Miracal d3 | Mrd3 | Mtn D3 | Nanod3 | Nexi d3 | Nikko 60k | Novocal d3 | Nu d3 | Nyle | Obvit d3 | Oh d3 | Ornovit d | Ostee d3 | Osteo calcirol | Ostospa | Pluss d3 | Popcal d3 | Power D3 | Problast d3 | Pure d3 | Quick d3 | Radcal d | Resi vd3 | Rio d3 | San d | Sayocal d3 | Secost | Sega d3 | Septa d3 | Shine d3 | Sol week | Solhike d3 | Solis d3 | Source d3 | Spycal d3 | Stamina D3 | Sun D3 | Sunbless | Sunde | Sunforce d3 | Sungem | Sunmix d3 | Sunrich d3 | Super D3 | Suprarize | Swot d3 | Talia d3 | Tayo | Tayo 7k | Trusd | Ultra d3 | Upmark d3 | Uprise d3 | Upsurge d3 | Uv 3 | Uvd3 | V d3 | Vd fit | Vd3 | Vdjub | Vilco d3 | Vitanova | Vitanox d3 | Vitastasis d3 | Vitcol D3 | Vitomin D3 | Wal d3 | Wal d3 plus | Week d3 | Wellbaby Vit D3 Drops | Xposun | Zindee;
  • (IQ) Iraq: Vita kid d3 | Vitadain d3 | Vitamin d3 kindi;
  • (IT) Italy: Annister | Annova | Balavita | Buonavit d3 | Colcad | Colecalciferolo doc | Colecalciferolo mylan | Colecalciferolo sandoz | Colecalciferolo teva | Decodi forte | Dibase | Dibaselab | Dicolev | Ditralia | Ditrevit 1000 | Fedivelle | Ibitred | Lampard | Medivid | Nodigap | Tomaino | Tredimin | Trevid | Vitenson | Xarenel | Xarexen | Xinovit D3 | Zibenak;
  • (JO) Jordan: Biodal | D3 fix | D3 max | Deferol | Dibase | Hi dee | Jamieson vitamin d | Jamieson vitamin d3 | Lynae vitamin d3 | Marnys vitamin d | New sana d3 | Pediakid vitamine d3 | Pediavit d | Sundown Vitamin D3 | Tera d3 | Topferol | Ultra d3 | Vidrop | Vitadad d3 | Vitalize vitamine D kids | Vitamin d | Wellbaby vit d;
  • (KE) Kenya: D3 must | Jusdee | Vita UVD3 | Vitoc d;
  • (KR) Korea, Republic of: Admin Forte | D mac | D3 base | Mega d3 | Orkey | Plus d | Vd | Vicholaid;
  • (KW) Kuwait: Biocyte vitamin d liposomal | D3 | Dibase | Euro D | Hebs nano d3 | Hi dee | Human essentials vitamin d | Infant D3 | Megavit D | Nature's truth d3 | Pediavit d | Vidrop | Vitamin d | Vitamin d3 | Vitbaby D | Vitbaby d comfort;
  • (LB) Lebanon: Acti d | Advancis vita d | Alto D | Benta d | Bio d3 | Bio-Vitamin D3 | Biodal | D | D ester | D Vita | D vital | D3 drops | Euro D | Health aid vitamin d3 | Infant D3 | Liquid D3 | Megavit D | Nu d3 | Ostiplus | Pediakid vitamine d3 | Pediavit d | Sun D3 | Vita D | Vitamin D 3 | Vitamin d3 | Vitamine D3;
  • (LT) Lithuania: Abc vit vitamin d3 | Adrigyl | Aquadetrim d3 | Baby D3 oily solution | Boncel | D max | D pearls | Debora | Detrical | Detritin | Devikap | Doppelherz aktiv vitamin d | Ecosh Vitamin d3 | Forday vitamin d3 | Gamtos namai vitaminas d3 | Ibuvit d | Jutavit d3 vitamin | Life vitamins d3 | Lifeplan vegan vitamin d3 | Lifeplan vitamin d3 | Livol extra vitamin d | Livsane vitamin d | Mega vitamin d | Molekin D3 | Nexovit d3 | Now vitamin d3 | Nutrivit d3 | Oiledixin vit d3 | Oilesen d3 | Oilesen vitaminas d3 | Oilidin forte | Oleovit d3 | Oriovit d | Senebra | Solfelix | Soli d | Ultra vitamin d | Videral | Vigantol | Vigantoletten | Viridkid vitamin d3 | Vitamin d | Vitamin d3 | Vitamina d3 | Vitaminas d3 | Vitaminas D3 farmax | Walmark mega vitamin d forte | You 2.0 vitamin d3;
  • (LU) Luxembourg: D cure | Fultivit d3 | Vigantol | Vigantoletten | Vitamin D3 hevert | Vitamine d will;
  • (LV) Latvia: Adrigyl | Aquadetrim d3 | Bertils vitamin d3 | Bobik D | Colief vitamin d3 | D max | D max kids | D pearls | D3 vitamins | D3 vitamins 100 | D3 vitamins max | Elite d3 vitamin | Forday vitamin d3 | Gold vit d max | Gold-vit d max | Lino complex baby | Livol extra vitamin d | Nateo d | Nateo d pilieni pro | Natugena vitamin d | Neo just d3 | Nexovit d3 | Nordvit vitamin d3 | Nordvit vitamin d3 forte | Oilesen d3 | Oilesen vitamin d3 | Olidetrim | Oriovit d | Oxidevit | Ultra vitamin d | Ultravit vitamin D3 | Videral | Vigantol | Vita D | Vitamin d | Vitamin d3 | Vitamin D3 ABCvit | Vitamins D3 | Vitamins d3 forte | Vitatabs d caps | Vitatabs Puru D;
  • (MA) Morocco: Curogyl d3 | D cure | D plus | D3 fix | Dossantos | Vitea d3;
  • (MX) Mexico: Demus | Detresgel | Milda | Morebon | Pausicaps | Valmetrol 3;
  • (MY) Malaysia: +P maxivit | Bio d3 | Duoleaf vitamin d3 | Nova vitamin d3 | Sunvite d3 | Trinley vitamin d3 | Uhc vitamin d3 | Vita d3 | Vitamin d3;
  • (NL) Netherlands: Cholecalcifer teva | Cholecalciferol 25.000 IE focus care | Cholecalciferol fagron | Cholecalciferol meditop | Cholecalciferol mylan | Colecalciferol Benferol | D cura | Davitamon Vitamine D Olie | Devaron | Divisun | Dynavit d3 | Flinndal vitamine d | Kruidvat vitamine d | Thorens | Vitamine d will | Vitamine d3 costero | Vitamine D3 Radaydrug;
  • (NO) Norway: Benferol | Bio d3 vitamin | Carlson vitamin d3 | Colecalciferol eql pharma | D3 50 | Dekristol | Desunin | Detremin | Divifarm | Divisun | Fultium | Metode vitamin d3 | Nycoplus d3 vitamin | Nycoplus vitamin d3 | Vigantol | Vitamin d3;
  • (NZ) New Zealand: Bioceuticals d3 | Cal.D | Cenovis vitamin d3 | D3 | Ethical nutrients daily d | Go pro vitamin d3 forte | Healtheries vit d | Liposomal D3 | Metagenics vitamin d3 | Nature's own vitamin d3 | Ostelin infant vitamin d3 | Ostelin vitamin d | Ostelin vitamin d3 | Osteovit D | Puria Vitamin D Drops | Radiance vitamin d3 chews | Sanderson premium vitamin d | Solgar vitamin d3 | Vit.D3 | Vitamin d3 | Wagner vegan vitamin d3;
  • (PE) Peru: Altad | Deblax | Deferol | Deltius | Enerd-3 | Farma D | Natures bounty d3 | Nuctis d | Pharmatech d vitamin | Vitamina d3 | Viton d3 | Wellnaris vitamin d3;
  • (PH) Philippines: Cholecalciferol | D vit | Fern d | Vita d max;
  • (PK) Pakistan: All d | Bonacta | Calciferol | Convell D | D 400 | D gain | D lite | D max | D one ultra | D zak | D zon | D3 | D4u | Dee 50k | Doplet | Doris | Dsun stat | Dx3 | Hiferol | Indrop d | Lifocal | Mac vitamin d3 | Milk d | Opt d | Oslia | Rite d | Sterol d | Sunbon | Sunny d | Sunnyd stat | Sunplex d | Sunplus | Vid tres;
  • (PL) Poland: Apod3 forte | D vitum | D3 optima baby | Dekristol | Dekristol pro | Detrical | Detritin | Devikap | Devisol 25 | Fultium d3 | Ibuvit d3 | Juvit d3 | Juvit kids d3 | Molekin d3 forte | Navigator vitamin d3 | Ostelavit | Solderol | Tarvit D3 | Vigalex forte | Vigalex Max | Vigantol | Vigantoletten | Vigantoletten max | Vitamin d3 | Vitaminum d3 | Vitole d | Vitrum D3 | Vitrum D3 forte | Xenivit witamina d;
  • (PR) Puerto Rico: Aqua d | Baby ddrops | Calcidol | Cholecalciferol | D | Decara | Infana d | Infants aqueous vitamin d oral drops | Kids Vitamin D3 | Mason vitamin d3 | Maximum D3 | Vit d3 | Vitamin d | Vitamin d3 | Zarbee's naturals baby vitamin D;
  • (PT) Portugal: Egostar | Molinar | Pravid | Vigantol;
  • (PY) Paraguay: Deblax | Nuctis d | Nuevi D | Nuevid | The vitamin shoppe d3 | Trevix | Viosterol | Vitamin d3;
  • (QA) Qatar: D-Vital | D3-Vicotrat | Devit-3 | Ditamin BabyVit D3 | Divad | Hi Dee | Sentinel Vitamin D3 | SunVit-D3 | Tera-D3 | Vita-D | Webber Naturals D3;
  • (RO) Romania: Vigantol | Vigantoletten | Vitamina d3;
  • (RU) Russian Federation: Aquadetrim | Complivit aqua D3 | D3 Kapelka | Detriferol | Detrimax vitamin d3 | Fortedetrim | Vigantol | Vitamin d3;
  • (SA) Saudi Arabia: D seul | D trol | Dibase | Divad | Jp vitamin d3 | Prima D3 | Ron D | Tera d | Topferol | Vi dal | Vidal | Vidrop | Vitamin d3;
  • (SE) Sweden: Benferol | Colecalciferol eql pharma | Colecalciferol meda | Colecalciferol Strides | D vitamin olja | D vitamin olja unimed | D vitamin Vatten | Detremin | Detrixin | Devitre | Divifarm | Divisun | Fultium | Kolekalciferol 2care4 | Kolekalciferol Ebb | Kolekalciferol Evolan | Vigantol;
  • (SG) Singapore: Baby ddrops | Baby's Vitamin D3 | Blackmores sunny d gold | Blackmores Vitamin d3 | Caltrate vitamin d daily | D ferol 1000 | D vite | Go vitamin d3 | Greenlife vitamin d3 | Guardian vitamin d3 | Helio d3 | Herbs of gold vitamin d3 | Minisun | Nature's essence vitamin d3 | Nordic naturals vitamin d3 | Nutrilife vitamin d | Ostelin vitamin d | Osteomed | Shaklee vita d3 | Swisse Ultiboost Vitamin D | Vitamin D 3 | Vitamin d3;
  • (SI) Slovenia: Oleovit d3 | Vitamin d | Vitamin d3 krka;
  • (SK) Slovakia: Fultium | Vigantol | Vitamin d | Vitamin d3 axonia;
  • (TH) Thailand: Blackmores sunny d3 daily | California gold nutrition vitamin d3 | Hello d | Vita d3 | Vitamin d3;
  • (TN) Tunisia: D max | Perla vit d3 | Physiokid vitamine d3 | Vicare vitamine d3;
  • (TR) Turkey: Calcivalen | Carlson kid's super daily d3 | Coledan | D coleflor | D colefor | D vitanol | D-3 ferol | D3 royal | D3 total | D3vigen | Denix vit d3 | Desiferol | Desiferol s | Devit d3 | Easyvit D | Forte d | Haver vitamin d3 | Maxvit d3 | Medicago vitamin d3 | Mnk vitamin d3 | Monovit d3 | Nbtlife vitamin d3 | Nutraxin vitamin d3 | Nutrivitd | Ocean vitamin d3 | Oli d3 | Onzela | Osende vitamin d3 | Pedia d | Probetic vitamin d3 | Purdevita vitamin d3 | Pure encapsulations vitamin d3 | Ress d3 | Ress kids d3 | Selovita d3 | Solgar vitamin d3 | Soliday d3 | Sovital vitamin d3 | Sundrop D3 | Tri d | Ultra vitamin d | Vegatamin d3 | Venatura kids vitamin d3 | Venatura vitamin d3 | Vi D3 | Vitade 3 | Vitagil gold vitamin d3 | Vitamin d | Vitamin d3 | Vitapure d3 | Vitario d3 vitamin | Viterol d3 | Vitoel D3 | Voonka vitamin d | Wellcare vitamin d3 intense | Zade vital d3 vitamini;
  • (TW) Taiwan: Baby's Vitamin D3 | Liquid P&B;
  • (UA) Ukraine: Aquadetrim d3 | Aquadetrim vitamin d3 | Coledan | Dekristol | Detrix | Videin | Vitamin d3;
  • (UG) Uganda: Jusdee;
  • (UY) Uruguay: Altad | D3 | D3 Vitex | Deblax | Detres | Gestavita d | Mulsi D3 | Mulsi d3 8000 | Nuctis d | Tresvit d | Viosterol | Viosterol forte | Vitamina D good'n natural;
  • (VE) Venezuela, Bolivarian Republic of: Deferol | Derovit | Farma D | Protevid | Vitamin d3;
  • (ZA) South Africa: Amipro daily d3 | Animal parade vitamin d3 | Biogen vitamin d3 | Bioplus vit-ality vitamin d3 | D drops | D tabs | D3 1000 IU | D3 5000 | Daily d3 | Daily D3 1000 | Essentials vitamin d3 | Foodstate vitamin d3 complex | Gold vitamin d3 | Grace vitamin d3 | Herbievite vitamin d3 | Metagenics d3 | Premium vitamin d3 | Provite d3 | Revite vitamin d | Soskain | Uvukahlale vitamin D3 | Vit a sun | Vital vitamin d3 | Vitamin D 3 | Vitamin d3 | Vitamin D3 Assist | Vitatech vitamin d3 | Vizinco d
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